Recombinant multi-species IL17/ IL17A/ CTLA-8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL17/IL17A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: IL17, gene name: IL17A, also named as CTLA-8, CTLA8, IL-17, IL-17A, IL17. This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T22095-Ag-1	Human IL17/IL17A protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T22095-Ag-1	Rat IL17/IL17A protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T22095-Ag-1	Mouse IL17/IL17A protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T22095-Ag-1	Cynomolgus/ Rhesus macaque IL17/IL17A protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T22095-Ag-1	Feline IL17/IL17A protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T22095-Ag-1	Canine IL17/IL17A protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T22095-Ag-1	Bovine IL17/IL17A protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T22095-Ag-1	Equine IL17/IL17A protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T22095-Ag, GM-Tg-rg-T22095-Ag, GM-Tg-mg-T22095-Ag, GM-Tg-cynog-T22095-Ag, GM-Tg-felg-T22095-Ag, GM-Tg-cang-T22095-Ag, GM-Tg-bovg-T22095-Ag, GM-Tg-equg-T22095-Ag-1
Products Name	IL17/IL17A protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	IL17
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL17/IL17A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.