DPP-4/DPP4: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of DPP-4/DPP4. The page also collects GeneMedi's different modalities and formats products for DPP-4 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the DPP-4 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]
|Gene Symbol and Synonyms||ACT3,ADABP,ADCP-I,ADCP2,CD26,Dpp-4,DPP4,DPPIV,THAM,TP103,WC10|
|Uniprot Entry Name||DPP4_HUMAN,DPP4_RAT,DPP4_FELCA,DPP4_BOVIN|
|Protein Sub-location||Transmembrane Protein|
|Category||Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target|
|Disease||Prostate Cancer, Ureteral obstruction, Diabetic Nephropathy|
|Target Classification||Checkpoint-Immuno Oncology|
Pre-made DPP-4-specific INN-index biosimilar (antibody&conjugates)
Anti-DPP-4 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
|Cat No.||Products Name (INN Index)||INN Name||Previous Name||Target||Format||Detail|
|GMP-Bios-ab-054||Pre-Made Begelomab biosimilar, Whole mAb, Anti-DPP4/DPP-4 Antibody: Anti-ADABP/ADCP2/CD26/DPPIV/TP103 therapeutic antibody||Begelomab||DPP4/DPP-4||Whole mAb||Detail|
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-DPP-4 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-DPP-4 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-DPP-4 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
|Antibody Name||Species||Format||Classified by tag||Detail|
|Anti-DPP-4/DPP4 monoclonal antibody||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||mab||FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody||Detail|
Multi-species DPP4/ DPP-4/ ADABP VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DPP-4/DPP4 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
|Products Name||Species||Expression Platform||Detail|
|DPP-4/DPP4 VLP (virus-like particle)||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||Mammalian cell||Products Developing|
Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse dipeptidylpeptidase 4 (DPP4) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Dipeptidyl peptidase-4?(DPP4), also known as?adenosine deaminase complexing protein 2?or?CD26?(cluster of differentiation?26) is a?protein?that, in humans, is encoded by the?DPP4?gene.DPP4 is related to?FAP,?DPP8, and?DPP9. The enzyme was discovered in 1966 by Hopsu-Havu and Glenner,?and as a result of various studies on chemism, was called dipeptidyl peptidase IV [DP IV]. The protein encoded by the DPP4 gene is an enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction, and apoptosis. It is a type II transmembrane glycoprotein, but a soluble form, which lacks the intracellular and transmembrane part, is present in blood plasma and various body fluids. DPP-4 is a serine exopeptidase that cleaves X-proline or X-alanine dipeptides from the N-terminus of polypeptides. Peptide bonds involving the cyclic amino acid proline cannot be cleaved by the majority of proteases and an N-terminal X-proline "shields" various biopeptides. Extracellular proline-specific proteases therefore play an important role in the regulation of these biopeptides.? DPP-4 is known to cleave a broad range of substrates including growth factors, chemokines, neuropeptides, and vasoactive peptides. The cleaved substrates lose their biological activity in the majority of cases, but in the case of the chemokine RANTES and neuropeptide Y, DPP-4 mediated cleavage leads to a shift in the receptor subtype binding.?? DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. Furthermore, it appears to work as a suppressor in the development of some tumors.?? DPP-4 also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
|Target||Species||Antigen Product Name||Bioactivity validation of Antigen||Antibody Product Name||Bioactivity validation of Antibodies||Detail|
|DPP4||Human, Cynomolgus/Rhesus macaque, rat, mouse||dipeptidylpeptidase 4 (DPP4) protein||Affintiy&bioactivity validated by ELISA, cell culture validated||Anti-DPP4 monoclonal antibody||Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).||Detail|
Click to check more Cytokine Products
Pre-made DPP4 viral vector in GM Promise-ORFTM
|Cat No.||Products name||NM ID||Species||Type||Detail|
|pGMAAV000048||mouse Dpp4 AAV plasmid||NM_010074.3||Mouse||AAV plasmid||Detail|
|vGMAAV000048||mouse Dpp4 AAV particle||NM_010074.3||Mouse||AAV particle||Detail|
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.