human, Cynomolgus/ Rhesus macaque, rat, mouse dipeptidylpeptidase 4(DPP4) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.


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Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse dipeptidylpeptidase 4 (DPP4) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Dipeptidyl peptidase-4 (DPP4), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene.DPP4 is related to FAP, DPP8, and DPP9. The enzyme was discovered in 1966 by Hopsu-Havu and Glenner, and as a result of various studies on chemism, was called dipeptidyl peptidase IV [DP IV]. The protein encoded by the DPP4 gene is an enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction, and apoptosis. It is a type II transmembrane glycoprotein, but a soluble form, which lacks the intracellular and transmembrane part, is present in blood plasma and various body fluids. DPP-4 is a serine exopeptidase that cleaves X-proline or X-alanine dipeptides from the N-terminus of polypeptides. Peptide bonds involving the cyclic amino acid proline cannot be cleaved by the majority of proteases and an N-terminal X-proline "shields" various biopeptides. Extracellular proline-specific proteases therefore play an important role in the regulation of these biopeptides. DPP-4 is known to cleave a broad range of substrates including growth factors, chemokines, neuropeptides, and vasoactive peptides. The cleaved substrates lose their biological activity in the majority of cases, but in the case of the chemokine RANTES and neuropeptide Y, DPP-4 mediated cleavage leads to a shift in the receptor subtype binding. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. Furthermore, it appears to work as a suppressor in the development of some tumors. DPP-4 also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.


Order information


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Catalog No.Product NameAntigen: Species
Antibody: Species Reactivity
SizePrice
GM-Tg-hg-T31391-Ag-1dipeptidylpeptidase 4 (DPP4) proteinhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T31391-Ab-1Anti-DPP4 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-hg-T31391-Ab-2Anti-DPP4 monoclonal antibodyhuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T31391-Ag-1dipeptidylpeptidase 4 (DPP4)rat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T31391-Ab-1Anti-DPP4 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T31391-Ab-2Anti-DPP4 monoclonal antibodyrat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T31391-Ag-1dipeptidylpeptidase 4 (DPP4)mouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T31391-Ab-1Anti-DPP4 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T31391-Ab-2Anti-DPP4 monoclonal antibodymouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T31391-Ag-1dipeptidylpeptidase 4 (DPP4)Cynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T31391-Ab-1Anti-DPP4 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T31391-Ab-2Anti-DPP4 monoclonal antibodyCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

Description


Target Information

Target NameDPP4
Full namedipeptidylpeptidase 4
Gene ID1803
Gene NameDPP4
Gene AliasADABP, ADCP2, CD26, DPPIV, TP103
Protein Sub-locationTransmembrane Protein

Antigen Information

Cat No.GM-Tg-hg-T31391-Ag-1, GM-Tg-rg-T31391-Ag-1, GM-Tg-mg-T31391-Ag-1, GM-Tg-cynog-T31391-Ag-1
Products Namedipeptidylpeptidase 4 (DPP4) protein
Specieshuman, Cynomolgus/ Rhesus macaque, rat, mouse
IsotypesRecombinant protein
Expression platformMammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated
TagHis
Product DescriptionRecombinant human, Cynomolgus/ Rhesus macaque, rat, mouse dipeptidylpeptidase 4 (DPP4) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
ApplicationCell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research, positive control for the diagnosis.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.GM-Tg-hg-T31391-Ab-1, GM-Tg-hg-T31391-Ab-2,
GM-Tg-rg-T31391-Ab-1, GM-Tg-rg-T31391-Ab-2,
GM-Tg-mg-T31391-Ab-1, GM-Tg-mg-T31391-Ab-2,
GM-Tg-cynog-T31391-Ab-1, GM-Tg-cynog-T31391-Ab-2
Products NameAnti-DPP-4/DPP4 monoclonal antibody
Formatmab
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
Species ReactivityHuman(H), Cynomolgus/Rhesus macaque(Cyno), rat(r), mouse(m)
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DPP-4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.