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ATIII/SERPINC1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of ATIII/SERPINC1. The page also collects GeneMedi's different modalities and formats products for ATIII in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the ATIII target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]

Target IDGM-T73476
Target NameATIII
Gene ID462,11905,304917,708854,480066,101093983,540261,100061173
Uniprot AccessionP01008,P41361
Uniprot Entry NameANT3_HUMAN,ANT3_BOVIN
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target
Gene EnsemblENSG00000117601
Target ClassificationN/A

Pre-made anti-ATIII inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-ATIII benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-ATIII mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-ATIII/SERPINC1 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail

Multi-species ANT3/ ATIII/ SERPINC1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATIII/SERPINC1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
ATIII/SERPINC1 VLP (virus-like particle)Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellProducts Developing

Pre-made SERPINC1 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMAAV000297human SERPINC1 AAV particleNM_000488.3HumanAAV particleDetail
pGMAAV000297human SERPINC1 AAV plasmidNM_000488.3HumanAAV plasmidDetail
vGMAAV000149human SERPINC1 AAV particleNM_000488.3HumanAAV particleDetail
pGMLP002891human SERPINC1 Lentivirus plasmidNM_000488HumanLentivirus plasmidDetail
vGMLP002891human SERPINC1 Lentivirus particleNM_000488HumanLentivirus particleDetail
pGMAAV000149human SERPINC1 AAV plasmidNM_000488.3HumanAAV plasmidDetail
pGMAD000029rat Serpinc1 Adenovirus plasmidNM_001012027RatAdenovirus plasmidDetail
pGMAAV000091mouse Serpinc1 AAV plasmidNM_080844.4MouseAAV plasmidDetail
vGMAD000029rat Serpinc1 Adenovirus particleNM_001012027RatAdenovirus particleDetail
vGMAAV000091mouse Serpinc1 AAV particleNM_080844.4MouseAAV particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.

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