CTNNB1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of CTNNB1. The page also collects GeneMedi's different modalities and formats products for CTNNB1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CTNNB1 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Target IDGM-T82795
Target NameCTNNB1
Gene ID1499,12387,84353,574265,477032,101097342,539003,100055241
Gene Symbol and Synonymsarmadillo,Bfc,Catnb,CTNNB,CTNNB1,EVR7,Jup,Mesc,MRD19,NEDSDV
Uniprot AccessionP35222,Q9WU82,B6V8E6,Q0VCX4
Uniprot Entry NameCTNB1_HUMAN,CTNB1_RAT,CTNB1_CANLF,CTNB1_BOVIN
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, Immuno-oncology Target
Diseasebreast cancer
Gene EnsemblENSG00000168036
Target ClassificationCheckpoint-Immuno Oncology, Pathway


Pre-made anti-CTNNB1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-CTNNB1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CTNNB1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-CTNNB1 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail



Multi-species CTNB1/ CTNNB1/ CTNNB VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CTNNB1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
CTNNB1 VLP (virus-like particle)Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellProducts Developing



Pre-made CTNNB1 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
pGMAD000646human CTNNB1 Adenovirus plasmidNM_001904HumanAdenovirus plasmidDetail
pGMLV000559human CTNNB1-mu Lentivirus plasmidNM_001098209.1HumanLentivirus plasmidDetail
vGMLP002747human CTNNB1 Lentivirus particleNM_001904HumanLentivirus particleDetail
vGMLV000559human CTNNB1-mu Lentivirus particleNM_001098209.1HumanLentivirus particleDetail
vGMAD000131human CTNNB1 Adenovirus particleNM_001904.3HumanAdenovirus particleDetail
pGMAD000131human CTNNB1 Adenovirus plasmidNM_001904.3HumanAdenovirus plasmidDetail
pGMAD000591human CTNNB1 Adenovirus plasmidNM_001904.1HumanAdenovirus plasmidDetail
vGMAD000591human CTNNB1 Adenovirus particleNM_001904.1HumanAdenovirus particleDetail
pGMLP002747human CTNNB1 Lentivirus plasmidNM_001904HumanLentivirus plasmidDetail
vGMAD000646human CTNNB1 Adenovirus particleNM_001904HumanAdenovirus particleDetail
pGMLV000041rat Ctnnb1 Lentivirus plasmidNM_053357.2RatLentivirus plasmidDetail
pGMLV000375mouse Ctnnb1 Lentivirus plasmidNM_001165902.1MouseLentivirus plasmidDetail
pGMLV000551Norway rat Ctnnb1 Lentivirus plasmidNM_053357.2Norway RatLentivirus plasmidDetail
pGMAD000596house mouse Ctnnb1 Adenovirus plasmidNM_001165902.1House MouseAdenovirus plasmidDetail
vGMLV000041rat Ctnnb1 Lentivirus particleNM_053357.2RatLentivirus particleDetail
vGMLV000375mouse Ctnnb1 Lentivirus particleNM_001165902.1MouseLentivirus particleDetail
vGMLV000551Norway rat Ctnnb1 Lentivirus particleNM_053357.2Norway RatLentivirus particleDetail
vGMAD000596house mouse Ctnnb1 Adenovirus particleNM_001165902.1House MouseAdenovirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.






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