BDNF: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of BDNF. The page also collects GeneMedi's different modalities and formats products for BDNF in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the BDNF target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
Target ID | GM-T93122 |
Target Name | BDNF |
Gene ID | 627,12064,24225,701245,403461,493690,617701,100009689 |
Gene Symbol and Synonyms | ANON2,BDNF,BULN2 |
Uniprot Accession | P23560,P23363,Q06225,Q7YRB4,Q9TST3,Q95106,Q0EAB7 |
Uniprot Entry Name | BDNF_HUMAN,BDNF_MACMU,BDNF_RAT,BDNF_FELCA,BDNF_CANLF,BDNF_BOVIN,BDNF_HORSE |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | Prostate Cancer, ovarian cancer, Overactive bladder, Autism, mental retardation, Allergic reactions, Asthma, Parkinson's Disease |
Gene Ensembl | ENSG00000176697 |
Target Classification | N/A |
Pre-made anti-BDNF inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-BDNF benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-BDNF mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-BDNF monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Recombinant multi-species BDNF/ ANON2/ BULN2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BDNF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
BDNF protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made BDNF viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMAD000577 | human BDNF Adenovirus particle | NM_170735.5 | Human | Adenovirus particle | Detail |
vGMLP004025 | human BDNF Lentivirus particle | BC029795 | Human | Lentivirus particle | Detail |
pGMLP004025 | human BDNF Lentivirus plasmid | BC029795 | Human | Lentivirus plasmid | Detail |
pGMAP000316 | Human BDNF Adenovirus plasmid | BC029795 | Human | Adenovirus plasmid | Detail |
vGMAP000316 | Human BDNF Adenovirus particle | BC029795 | Human | Adenovirus particle | Detail |
pGMAD000577 | human BDNF Adenovirus plasmid | NM_170735.5 | Human | Adenovirus plasmid | Detail |
pGMLV000169 | mouse Bdnf Lentivirus plasmid | NM_007540.4 | Mouse | Lentivirus plasmid | Detail |
pGMLV000564 | house mouse bdnf Lentivirus plasmid | NM_007540.4 | House Mouse | Lentivirus plasmid | Detail |
pGMAAV000124 | rat Bdnf AAV plasmid | NM_001270630 | Rat | AAV plasmid | Detail |
pGMAAV000220 | house mouse Bdnf AAV plasmid | NM_007540 | House Mouse | AAV plasmid | Detail |
pGMAAV000286 | Norway rat Bdnf AAV plasmid | NM_001270630.1 | Norway Rat | AAV plasmid | Detail |
vGMLV000169 | mouse Bdnf Lentivirus particle | NM_007540.4 | Mouse | Lentivirus particle | Detail |
vGMLV000564 | house mouse bdnf Lentivirus particle | NM_007540.4 | House Mouse | Lentivirus particle | Detail |
vGMAAV000124 | rat Bdnf AAV particle | NM_001270630 | Rat | AAV particle | Detail |
vGMAAV000220 | house mouse Bdnf AAV particle | NM_007540 | House Mouse | AAV particle | Detail |
vGMAAV000286 | Norway rat Bdnf AAV particle | NM_001270630.1 | Norway Rat | AAV particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.