Anti-BDNF/ ANON2/ BULN2 functional antibody

Anti-BDNF/ ANON2/ BULN2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to BDNF/BDNF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T93122-Ab-1/ GM-Tg-hg-T93122-Ab-2Anti-Human BDNF monoclonal antibodyHuman
GM-Tg-rg-T93122-Ab-1/ GM-Tg-rg-T93122-Ab-2Anti-Rat BDNF monoclonal antibodyRat
GM-Tg-mg-T93122-Ab-1/ GM-Tg-mg-T93122-Ab-2Anti-Mouse BDNF monoclonal antibodyMouse
GM-Tg-cynog-T93122-Ab-1/ GM-Tg-cynog-T93122-Ab-2Anti-Cynomolgus/ Rhesus macaque BDNF monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T93122-Ab-1/ GM-Tg-felg-T93122-Ab-2Anti-Feline BDNF monoclonal antibodyFeline
GM-Tg-cang-T93122-Ab-1/ GM-Tg-cang-T93122-Ab-2Anti-Canine BDNF monoclonal antibodyCanine
GM-Tg-bovg-T93122-Ab-1/ GM-Tg-bovg-T93122-Ab-2Anti-Bovine BDNF monoclonal antibodyBovine
GM-Tg-equg-T93122-Ab-1/ GM-Tg-equg-T93122-Ab-2Anti-Equine BDNF monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T93122-Ab-1/ GM-Tg-hg-T93122-Ab-2; GM-Tg-rg-T93122-Ab-1/ GM-Tg-rg-T93122-Ab-2;
GM-Tg-mg-T93122-Ab-1/ GM-Tg-mg-T93122-Ab-2; GM-Tg-cynog-T93122-Ab-1/ GM-Tg-cynog-T93122-Ab-2;
GM-Tg-felg-T93122-Ab-1/ GM-Tg-felg-T93122-Ab-2; GM-Tg-cang-T93122-Ab-1/ GM-Tg-cang-T93122-Ab-2;
GM-Tg-bovg-T93122-Ab-1/ GM-Tg-bovg-T93122-Ab-2; GM-Tg-equg-T93122-Ab-1/ GM-Tg-equg-T93122-Ab-2
Products NameAnti-BDNF monoclonal antibody
Formatmab
Target NameBDNF
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-BDNF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T93122-Ag-1Recombinant multi-species BDNF/ ANON2/ BULN2 protein
    ORF Viral VectorvGMAD000577human BDNF Adenovirus particle
    ORF Viral VectorvGMLP004025human BDNF Lentivirus particle
    ORF Viral VectorpGMLP004025human BDNF Lentivirus plasmid
    ORF Viral VectorpGMAP000316Human BDNF Adenovirus plasmid
    ORF Viral VectorvGMAP000316Human BDNF Adenovirus particle
    ORF Viral VectorpGMAD000577human BDNF Adenovirus plasmid
    ORF Viral VectorpGMLV000169mouse Bdnf Lentivirus plasmid
    ORF Viral VectorpGMLV000564house mouse bdnf Lentivirus plasmid
    ORF Viral VectorpGMAAV000124rat Bdnf AAV plasmid
    ORF Viral VectorpGMAAV000220house mouse Bdnf AAV plasmid
    ORF Viral VectorpGMAAV000286Norway rat Bdnf AAV plasmid
    ORF Viral VectorvGMLV000169mouse Bdnf Lentivirus particle
    ORF Viral VectorvGMLV000564house mouse bdnf Lentivirus particle
    ORF Viral VectorvGMAAV000124rat Bdnf AAV particle
    ORF Viral VectorvGMAAV000220house mouse Bdnf AAV particle
    ORF Viral VectorvGMAAV000286Norway rat Bdnf AAV particle


    Target information

    Target IDGM-T93122
    Target NameBDNF
    Gene ID627,12064,24225,701245,403461,493690,617701,100009689
    Gene Symbol and SynonymsANON2,BDNF,BULN2
    Uniprot AccessionP23560,P23363,Q06225,Q7YRB4,Q9TST3,Q95106,Q0EAB7
    Uniprot Entry NameBDNF_HUMAN,BDNF_MACMU,BDNF_RAT,BDNF_FELCA,BDNF_CANLF,BDNF_BOVIN,BDNF_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target
    DiseaseProstate Cancer, ovarian cancer, Overactive bladder, Autism, mental retardation, Allergic reactions, Asthma, Parkinson's Disease
    Gene EnsemblENSG00000176697
    Target ClassificationN/A

    The target: BDNF, gene name: BDNF, also named as ANON2, BULN2. This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.