Human APOE/AD2/ APO-E ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_000041.3)
Pre-made Human APOE/AD2/ APO-E Adeno-associated virus expression plasmid (ITR-vector) for APOE AAV packaging, APOE AAV production.The purified Human APOE/AD2/ APO-E AAV particle serves as an invaluable asset for in-depth in vivo APOE studies, mechanism of action (MOA) research, and the evolution of APOE-associated gene therapy strategies.
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Product information
Catalog No. | Product Name | Plasmid Grade | Plasmid quantity |
---|---|---|---|
pGMAAV000334 | Human APOE Adeno-associate virus(AAV) plasmid | Research Grade | 10mg, 50mg, 100mg, 500mg, >1g |
GMP-like Grade | 10mg, 50mg, 100mg, 500mg, >1g | ||
High Quality (HQ) Grade | |||
Seed | 5ug |
Product Description
Catalog ID | pGMAAV000334 |
Gene Name | APOE |
Accession Number | NM_000041.3 |
Gene ID | 348 |
Species | Human |
Product Type | Adeno-associate virus(AAV) plasmid (overexpression) |
Insert Length | 954 bp |
Gene Alias | AD2, APO-E, ApoE4, LDLCQ5, LPG |
Fluorescent Reporter | EGFP |
Mammalian Cell Selection | |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-T21689-Ab | Anti-APOE/ AD2/ APO-E monoclonal antibody |
Target Antigen | GM-Tg-g-T21689-Ag | APOE VLP (virus-like particle) |
ORF Viral Vector | pGMLV001748 | Human APOE Lentivirus plasmid |
ORF Viral Vector | pGMAAV000334 | Human APOE Adeno-associate virus(AAV) plasmid |
ORF Viral Vector | pGMLP001912 | Human APOE Lentivirus plasmid |
ORF Viral Vector | vGMLV001748 | Human APOE Lentivirus particle |
ORF Viral Vector | vGMAAV000334 | Human APOE Adeno-associate virus(AAV) particle |
ORF Viral Vector | vGMLP001912 | Human APOE Lentivirus particle |
ORF Viral Vector | pGMLV002187 | Mouse Apoe Lentivirus plasmid |
Target information
Target ID | GM-T21689 |
Target Name | APOE |
Gene ID | 348, 11816, 714623, 25728, 101086769, 476438, 281004, 100065481 |
Gene Symbol and Synonyms | AD2,APO-E,APOE,ApoE4,APOEA,LDLCQ5,LPG |
Uniprot Accession | P02649 |
Uniprot Entry Name | APOE_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Diagnostics Biomarker |
Disease | Type 1 diabetes mellitus, Alzheimer's Disease, Breast neoplasms, Dent disease, Malignant neoplasm of bladder, Other diseases of intestines (K55-K64) |
Gene Ensembl | ENSG00000130203 |
Target Classification | Not Available |
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
About GMVC
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