Human APOE/AD2/ APO-E ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_000041.3)

Pre-made Human APOE/AD2/ APO-E Adeno-associated virus expression plasmid (ITR-vector) for APOE AAV packaging, APOE AAV production.The purified Human APOE/AD2/ APO-E AAV particle serves as an invaluable asset for in-depth in vivo APOE studies, mechanism of action (MOA) research, and the evolution of APOE-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

Target products collectionGo to APOE/AD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)



Product information

Catalog No. Product Name Plasmid Grade Plasmid quantity
pGMAAV000334 Human APOE Adeno-associate virus(AAV) plasmid Research Grade 10mg, 50mg, 100mg, 500mg, >1g
GMP-like Grade 10mg, 50mg, 100mg, 500mg, >1g
High Quality (HQ) Grade
Seed 5ug


Product Description

Catalog ID pGMAAV000334
Gene Name APOE
Accession Number NM_000041.3
Gene ID 348
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 954 bp
Gene Alias AD2, APO-E, ApoE4, LDLCQ5, LPG
Fluorescent Reporter EGFP
Mammalian Cell Selection
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T21689-Ab Anti-APOE/ AD2/ APO-E monoclonal antibody
    Target Antigen GM-Tg-g-T21689-Ag APOE VLP (virus-like particle)
    ORF Viral Vector pGMLV001748 Human APOE Lentivirus plasmid
    ORF Viral Vector pGMAAV000334 Human APOE Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMLP001912 Human APOE Lentivirus plasmid
    ORF Viral Vector vGMLV001748 Human APOE Lentivirus particle
    ORF Viral Vector vGMAAV000334 Human APOE Adeno-associate virus(AAV) particle
    ORF Viral Vector vGMLP001912 Human APOE Lentivirus particle
    ORF Viral Vector pGMLV002187 Mouse Apoe Lentivirus plasmid


    Target information

    Target ID GM-T21689
    Target Name APOE
    Gene ID 348, 11816, 714623, 25728, 101086769, 476438, 281004, 100065481
    Gene Symbol and Synonyms AD2,APO-E,APOE,ApoE4,APOEA,LDLCQ5,LPG
    Uniprot Accession P02649
    Uniprot Entry Name APOE_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Diagnostics Biomarker
    Disease Type 1 diabetes mellitus, Alzheimer's Disease, Breast neoplasms, Dent disease, Malignant neoplasm of bladder, Other diseases of intestines (K55-K64)
    Gene Ensembl ENSG00000130203
    Target Classification Not Available

    The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]



    About GMVC

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    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.