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Anti-APOE/ AD2/ APO-E monoclonal antibody
Anti-APOE/ AD2/ APO-E antibody for FACS & in-vivo assay
Go to APOE/APOE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T21689-Ab-1/ GM-Tg-hg-T21689-Ab-2 | Anti-Human APOE monoclonal antibody | Human |
| GM-Tg-rg-T21689-Ab-1/ GM-Tg-rg-T21689-Ab-2 | Anti-Rat APOE monoclonal antibody | Rat |
| GM-Tg-mg-T21689-Ab-1/ GM-Tg-mg-T21689-Ab-2 | Anti-Mouse APOE monoclonal antibody | Mouse |
| GM-Tg-cynog-T21689-Ab-1/ GM-Tg-cynog-T21689-Ab-2 | Anti-Cynomolgus/ Rhesus macaque APOE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T21689-Ab-1/ GM-Tg-felg-T21689-Ab-2 | Anti-Feline APOE monoclonal antibody | Feline |
| GM-Tg-cang-T21689-Ab-1/ GM-Tg-cang-T21689-Ab-2 | Anti-Canine APOE monoclonal antibody | Canine |
| GM-Tg-bovg-T21689-Ab-1/ GM-Tg-bovg-T21689-Ab-2 | Anti-Bovine APOE monoclonal antibody | Bovine |
| GM-Tg-equg-T21689-Ab-1/ GM-Tg-equg-T21689-Ab-2 | Anti-Equine APOE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T21689-Ab-1/ GM-Tg-hg-T21689-Ab-2; GM-Tg-rg-T21689-Ab-1/ GM-Tg-rg-T21689-Ab-2; GM-Tg-mg-T21689-Ab-1/ GM-Tg-mg-T21689-Ab-2; GM-Tg-cynog-T21689-Ab-1/ GM-Tg-cynog-T21689-Ab-2; GM-Tg-felg-T21689-Ab-1/ GM-Tg-felg-T21689-Ab-2; GM-Tg-cang-T21689-Ab-1/ GM-Tg-cang-T21689-Ab-2; GM-Tg-bovg-T21689-Ab-1/ GM-Tg-bovg-T21689-Ab-2; GM-Tg-equg-T21689-Ab-1/ GM-Tg-equg-T21689-Ab-2 |
| Products Name | Anti-APOE monoclonal antibody |
| Format | mab |
| Target Name | APOE |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-APOE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species APOE/ AD2/ APO-E VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001912 | human APOE Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000334 | human APOE AAV particle |
| ORF Viral Vector | vGMLP001912 | human APOE Lentivirus particle |
| ORF Viral Vector | pGMAAV000334 | human APOE AAV plasmid |
| ORF Viral Vector | pGMLPm000901 | mouse Apoe Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000901 | mouse Apoe Lentivirus particle |
Target information
| Target ID | GM-T21689 |
| Target Name | APOE |
| Gene ID | 348,11816,25728,714623,476438,101086769,281004,100065481 |
| Gene Symbol and Synonyms | AD2,APO-E,APOE,ApoE4,APOEA,LDLCQ5,LPG |
| Uniprot Accession | P02649,P02650,Q28502,P18649,Q03247 |
| Uniprot Entry Name | APOE_HUMAN,APOE_MACMU,APOE_RAT,APOE_CANLF,APOE_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | Type 1 diabetes mellitus, Alzheimer's Disease, Breast neoplasms, Dent disease, Malignant neoplasm of bladder, Other diseases of intestines (K55-K64) |
| Gene Ensembl | ENSG00000130203 |
| Target Classification | N/A |
The target: APOE, gene name: APOE, also named as AD2, APO-E, ApoE4, LDLCQ5, LPG. The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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