Human PTGDS/L-PGDS/LPGDS ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_000954)

Cat. No.: pGMAAV001623
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human PTGDS/L-PGDS/LPGDS Adeno-associated virus expression plasmid (ITR-vector) for PTGDS AAV packaging, PTGDS AAV production.The purified Human PTGDS/L-PGDS/LPGDS AAV particle serves as an invaluable asset for in-depth in vivo PTGDS studies, mechanism of action (MOA) research, and the evolution of PTGDS-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV001623
Gene Name PTGDS
Accession Number NM_000954
Gene ID 5730
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 573 bp
Gene Alias L-PGDS,LPGDS,PDS,PGD2,PGDS,PGDS2
Fluorescent Reporter Null
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter CTNT
Resistance Amplicin
ORF Nucleotide Sequence ATGGCTACTCATCACACACTGTGGATGGGACTGGCCCTGCTGGGGGTGCTGGGCGACCTGCAGGCAGCACCGGAGGCCCAGGTCTCCGTGCAGCCCAACTTCCAGCAGGACAAGTTCCTGGGGCGCTGGTTCAGCGCGGGCCTCGCCTCCAACTCGAGCTGGCTCCGGGAGAAGAAGGCGGCGTTGTCCATGTGCAAGTCTGTGGTGGCCCCTGCCACGGATGGTGGCCTCAACCTGACCTCCACCTTCCTCAGGAAAAACCAGTGTGAGACCCGAACCATGCTGCTGCAGCCCGCGGGGTCCCTCGGCTCCTACAGCTACCGGAGTCCCCACTGGGGCAGCACCTACTCCGTGTCAGTGGTGGAGACCGACTACGACCAGTACGCGCTGCTGTACAGCCAGGGCAGCAAGGGCCCTGGCGAGGACTTCCGCATGGCCACCCTCTACAGCCGAACCCAGACCCCCAGGGCTGAGTTAAAGGAGAAATTCACCGCCTTCTGCAAGGCCCAGGGCTTCACAGAGGATACCATTGTCTTCCTGCCCCAAACCGATAAGTGCATGACGGAACAATAG
ORF Protein Sequence MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-SE1229-Ab Anti-PTGDS/ L-PGDS/ LPGDS functional antibody
    Target Antigen GM-Tg-g-SE1229-Ag PTGDS protein
    ORF Viral Vector pGMLP002273 Human PTGDS Lentivirus plasmid
    ORF Viral Vector pGMAAV001623 Human PTGDS Adeno-associate virus(AAV) plasmid
    ORF Viral Vector vGMLP002273 Human PTGDS Lentivirus particle
    ORF Viral Vector vGMAAV001623 Human PTGDS Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-SE1229
    Target Name PTGDS
    Gene ID 5730, 19215, 707990, 25526, 493852, 403740, 286858, 100067921
    Gene Symbol and Synonyms 21kDa,L-PGDS,LPGDS,PDS,PGD2,PGDS,PGDS2,PH2DISO,PTGDS,Ptgs3
    Uniprot Accession P41222
    Uniprot Entry Name PTGDS_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Not Available
    Disease Drug-Induced Nephropathy, Contrast - Induced Nephropathy, Diabetic Nephropathy, Lupus Glomerulonephritis
    Gene Ensembl ENSG00000107317
    Target Classification Not Available

    The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]



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