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Anti-PTGDS/ L-PGDS/ LPGDS functional antibody
Anti-PTGDS/ L-PGDS/ LPGDS functional antibody for cell culture, ELISA & in-vivo assay
Go to PTGDS/PTGDS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1229-Ab-1/ GM-Tg-hg-SE1229-Ab-2 | Anti-Human PTGDS monoclonal antibody | Human |
| GM-Tg-rg-SE1229-Ab-1/ GM-Tg-rg-SE1229-Ab-2 | Anti-Rat PTGDS monoclonal antibody | Rat |
| GM-Tg-mg-SE1229-Ab-1/ GM-Tg-mg-SE1229-Ab-2 | Anti-Mouse PTGDS monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1229-Ab-1/ GM-Tg-cynog-SE1229-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTGDS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1229-Ab-1/ GM-Tg-felg-SE1229-Ab-2 | Anti-Feline PTGDS monoclonal antibody | Feline |
| GM-Tg-cang-SE1229-Ab-1/ GM-Tg-cang-SE1229-Ab-2 | Anti-Canine PTGDS monoclonal antibody | Canine |
| GM-Tg-bovg-SE1229-Ab-1/ GM-Tg-bovg-SE1229-Ab-2 | Anti-Bovine PTGDS monoclonal antibody | Bovine |
| GM-Tg-equg-SE1229-Ab-1/ GM-Tg-equg-SE1229-Ab-2 | Anti-Equine PTGDS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1229-Ab-1/ GM-Tg-hg-SE1229-Ab-2; GM-Tg-rg-SE1229-Ab-1/ GM-Tg-rg-SE1229-Ab-2; GM-Tg-mg-SE1229-Ab-1/ GM-Tg-mg-SE1229-Ab-2; GM-Tg-cynog-SE1229-Ab-1/ GM-Tg-cynog-SE1229-Ab-2; GM-Tg-felg-SE1229-Ab-1/ GM-Tg-felg-SE1229-Ab-2; GM-Tg-cang-SE1229-Ab-1/ GM-Tg-cang-SE1229-Ab-2; GM-Tg-bovg-SE1229-Ab-1/ GM-Tg-bovg-SE1229-Ab-2; GM-Tg-equg-SE1229-Ab-1/ GM-Tg-equg-SE1229-Ab-2 |
| Products Name | Anti-PTGDS monoclonal antibody |
| Format | mab |
| Target Name | PTGDS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTGDS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1229-Ag-1 | Recombinant multi-species PTGDS/ L-PGDS/ LPGDS protein |
| ORF Viral Vector | pGMLP002273 | human PTGDS Lentivirus plasmid |
| ORF Viral Vector | vGMLP002273 | human PTGDS Lentivirus particle |
| ORF Viral Vector | pGMLPm000733 | mouse Ptgds Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000733 | mouse Ptgds Lentivirus particle |
Target information
| Target ID | GM-SE1229 |
| Target Name | PTGDS |
| Gene ID | 5730,19215,25526,707990,403740,493852,286858,100067921 |
| Gene Symbol and Synonyms | 21kDa,L-PGDS,LPGDS,PDS,PGD2,PGDS,PGDS2,PH2DISO,PTGDS,Ptgs3 |
| Uniprot Accession | P41222,P22057,Q9XS65,Q29487,O02853,O97921 |
| Uniprot Entry Name | PTGDS_HUMAN,PTGDS_RAT,PTGDS_FELCA,PTGDS_CANLF,PTGDS_BOVIN,PTGDS_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Drug-Induced Nephropathy, Contrast - Induced Nephropathy, Diabetic Nephropathy, Lupus Glomerulonephritis |
| Gene Ensembl | ENSG00000107317 |
| Target Classification | N/A |
The target: PTGDS, gene name: PTGDS, also named as L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2. The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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