Bovine Respiratory Syncytial Virus antibody and antigen (recombinant protein)

Diagnostic anti-Bovine Respiratory Syncytial Virus antibodies pairs and antigen for animal health (animal Bovines/Cattle infectious disease Bovine Respiratory Syncytial Virus infection) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P066-Ag01 Recombinant Bovine Respiratory Syncytial Virus protein $3090.00
GMP-VT-P066-Ab01 Anti-Bovine Respiratory Syncytial Virus mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P066-Ab02 Anti-Bovine Respiratory Syncytial Virus mouse monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P066-Ag01
Product Name Recombinant Bovine Respiratory Syncytial Virus protein
Pathogen Bovine Respiratory Syncytial Virus
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Bovine Respiratory Syncytial Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Bovine Respiratory Syncytial Virus level test of animal Bovines/Cattle infectious disease with Bovine Respiratory Syncytial Virus infection.
Tag His
Product description Recombinant Bovine Respiratory Syncytial Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P066-Ab01,GMP-VT-P066-Ab02
Pathogen Bovine Respiratory Syncytial Virus
Product Name Anti-Bovine Respiratory Syncytial Virus mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Bovine Respiratory Syncytial Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Respiratory Syncytial Virus antibodies in Bovine Respiratory Syncytial Virus level test of animal Bovines/Cattle infectious disease with Bovine Respiratory Syncytial Virus infection.
Product description Anti-Bovine Respiratory Syncytial Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine Respiratory Syncytial Virus antibodies./td>
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen


    Bovine Respiratory Syncytial Virus (BRSV) is a pathogenic virus that infects cattle, causing acute respiratory disease with a high morbidity rate in calves. This highly contagious virus can cause severe economic losses and animal welfare concerns in the livestock industry.

    BRSV is a member of the Paramyxoviridae family, which includes many other important animal and human pathogens, such as measles virus, human respiratory syncytial virus (HRSV), and Newcastle disease virus. The virion of BRSV consists of an enveloped RNA genome, containing a single-stranded negative-sense RNA molecule that encodes 11 proteins, including the nucleoprotein (N), phosphoprotein (P), matrix protein (M), fusion protein (F), attachment glycoprotein (G), small hydrophobic protein (SH), and large polymerase protein (L). The F and G proteins are the crucial envelope glycoproteins visible on the surface of the viral particle, which determine the viral tropism and host range, and are key targets for host immune responses.

    Bovine respiratory disease complex (BRDC), which is mainly characterized by pneumonia in cattle, is one of the most prevalent infectious diseases affecting the cattle industry worldwide. BRSV is considered one of the primary viral pathogens contributing to BRDC. The disease affects all ages of cattle, but severity and mortality are higher in young animals, especially calves between 2-6 months old. The transmission of BRSV occurs primarily through aerosols, direct contact, or fomites.

    Clinical signs of BRSV infection typically appear 2-5 days after exposure to the virus and include depression, coughing, fever, nasal discharge, and dyspnea. The respiratory signs result from damage to the lung tissues and bronchial epithelium caused by viral replication and subsequent host immune responses.

    There are several diagnostic methods available for BRSV infection. Virus isolation in cell culture and antigen detection by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA) are conventional methods used for BRSV diagnosis. However, these methods are time-consuming and require specialized training and equipment. Serological tests such as the complement fixation test (CFT), indirect fluorescent antibody test (IFAT), and enzyme-linked immunosorbent assay (ELISA) can detect specific antibodies against BRSV in serum, indicating previous exposure or infection.

    Nucleic acid detection methods such as reverse transcription polymerase chain reaction (RT-PCR) and real-time RT-PCR are widely used for laboratory diagnosis of BRSV infection. These molecular techniques can detect BRSV RNA in clinical samples such as nasal swabs, lung tissues, and bronchoalveolar lavage fluid. RT-PCR assays targeting the F and G genes of BRSV are commonly used for detecting and differentiating BRSV from other bovine respiratory viruses.

    In conclusion, Bovine Respiratory Syncytial Virus (BRSV) is a significant pathogen affecting the cattle industry worldwide. Understanding the structure, transmission, clinical signs, and diagnostic methods of BRSV is crucial to prevent and control the disease. Further research is needed to develop more effective vaccines and antiviral strategies to control BRSV infection and reduce its economic impact on the livestock industry.



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