Infectious Pancreatic Necrosis Virus antibody and antigen (recombinant protein)

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Diagnostic anti-Infectious Pancreatic Necrosis Virus antibodies pairs and antigen for animal health (animal Juvenile salmonids infectious disease Infectious pancreatic necrosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P229-Ag01	Recombinant Infectious Pancreatic Necrosis Virus protein	$3090.00
GMP-VT-P229-Ab01	Anti-Infectious Pancreatic Necrosis Virus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P229-Ab02	Anti-Infectious Pancreatic Necrosis Virus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P229-Ag01
Product Name	Recombinant Infectious Pancreatic Necrosis Virus protein
Pathogen	Infectious Pancreatic Necrosis Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Infectious Pancreatic Necrosis Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Infectious Pancreatic Necrosis Virus level test of animal Juvenile salmonids infectious disease with Infectious pancreatic necrosis.
Tag	His
Product description	Recombinant Infectious Pancreatic Necrosis Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P229-Ab01,GMP-VT-P229-Ab02
Pathogen	Infectious Pancreatic Necrosis Virus
Product Name	Anti-Infectious Pancreatic Necrosis Virus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Infectious Pancreatic Necrosis Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Pancreatic Necrosis Virus antibodies in Infectious Pancreatic Necrosis Virus level test of animal Juvenile salmonids infectious disease with Infectious pancreatic necrosis.
Product description	Anti-Infectious Pancreatic Necrosis Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Pancreatic Necrosis Virus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Infectious Pancreatic Necrosis Virus (IPNV) is a pathogen that causes a serious viral disease known as Infectious Pancreatic Necrosis (IPN) in salmonid fish species such as trout and salmon. IPN can result in significant economic losses for the aquaculture industry due to high mortality rates, reduced growth, and decreased marketability of affected fish.

IPNV belongs to the family Birnaviridae, which contains other important animal viruses such as infectious bursal disease virus (IBDV) in poultry and Drosophila X virus in insects. The genus Aquabirnavirus is comprised of aquatic birnaviruses that infect fish and shellfish. IPNV is a non-enveloped, approximately 70-nm diameter icosahedral particle with a double-stranded RNA genome consisting of two segments.

Segment A encodes for the major capsid protein VP2, which forms the outer shell of the virus and plays a crucial role in its replication and survival. VP2 is a highly antigenic protein that elicits strong adaptive immune responses to IPNV infection in fish. VP2-based vaccines have been developed and are used widely for IPNV control.

Segment B encodes for VP1, a protein essential for viral replication and transcription, as well as other nonstructural proteins whose function is not yet fully understood. VP1 has also been studied extensively as a potential target for antiviral therapy against IPNV.

IPNV can infect fish at all stages of development, but younger fish are generally more susceptible to the virus than older ones. The virus can be transmitted horizontally via contaminated water or vertically from infected broodstock to offspring. Clinical signs of IPN in fish include lethargy, anorexia, darkening of the skin, and abdominal distension. Fish may float at the water surface or exhibit erratic swimming behavior due to neurological damage caused by the virus.

Several methods are available for detecting IPNV infection in fish, including virus isolation, electron microscopy, antigen detection tests, and molecular assays such as PCR and real-time PCR. These methods are based on the detection of viral particles, viral proteins, or viral nucleic acids in fish tissues or fluids. The sensitivity and specificity of these methods vary depending on the target and the sample type.

In conclusion, IPNV is a significant pathogen affecting salmonid aquaculture worldwide. Understanding the structure, replication, and transmission of the virus is essential for developing effective control measures against IPNV infection. The development of novel antiviral drugs and vaccines will also help reduce the impact of this disease on the aquaculture industry.

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