TNFSF13B: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of TNFSF13B. The page also collects GeneMedi's different modalities and formats products for TNFSF13B in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TNFSF13B target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Target ID	GM-T02318
Target Name	TNFSF13B
Gene ID	10673,24099,498666,693917,485545,101088640,504507,100051550
Gene Symbol and Synonyms	BAFF,BLYS,CD257,D8Ertd387e,DTL,RGD1561519,TALL-1,TALL1,THANK,TNFSF13B,TNFSF20,TNLG7A,ZTNF4
Uniprot Accession	Q9Y275
Uniprot Entry Name	TN13B_HUMAN
Protein Sub-location	Transmembrane Protein
Category	Therapeutics Target, INN Index, Cytokine Target
Disease	Lupus Glomerulonephritis
Gene Ensembl	ENSG00000102524
Target Classification	N/A

Pre-made TNFSF13B-specific INN-index biosimilar (antibody&conjugates)

Anti-TNFSF13B therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.	Products Name (INN Index)	INN Name	Previous Name	Target	Format	Detail
GMP-Bios-INN-1018	Pre-Made Telitacicept Biosimilar, Fusion Protein targeting TNFSF13B fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting BAFF/BLYS/CD257/DTL/TALL-1/TALL1/THANK/TNFSF20/TNLG7A/ZTNF4	telitacicept		TNFSF13B	Fusion Protein	Detail
GMP-Bios-ab-540	Pre-Made Tabalumab biosimilar, Whole mAb, Anti-TNFSF13B Antibody: Anti-BAFF/BLYS/CD257/DTL/TALL-1/TALL1/THANK/TNFSF20/TNLG7A/ZTNF4 therapeutic antibody	Tabalumab		TNFSF13B	Whole mAb	Detail
GMP-Bios-INN-767	Pre-Made Briobacept Biosimilar, Fusion Protein targeting TNFSF13B fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting BAFF/BLYS/CD257/DTL/TALL-1/TALL1/THANK/TNFSF20/TNLG7A/ZTNF4	briobacept		TNFSF13B	Fusion Protein	Detail
GMP-Bios-ab-056	Pre-Made Belimumab biosimilar, Whole mAb, Anti-TNFSF13B Antibody: Anti-BAFF/BLYS/CD257/DTL/TALL-1/TALL1/THANK/TNFSF20/TNLG7A/ZTNF4 therapeutic antibody	Belimumab		TNFSF13B	Whole mAb	Detail
GMP-Bios-ab-568	Pre-Made Tibulizumab biosimilar, Bispecific Mixed mAb and scFv, Anti-TNFSF13B;IL17A/IL17 Antibody: Anti-BAFF/BLYS/CD257/DTL/TALL-1/TALL1/THANK/TNFSF20/TNLG7A/ZTNF4;CTLA-8/CTLA8A therapeutic antibody	Tibulizumab		TNFSF13B;IL17A/IL17	Bispecific Mixed mAb and scFv	Detail
GMP-Bios-INN-764	Pre-Made Blisibimod Biosimilar, Fusion Protein targeting TNFSF13B fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting BAFF/BLYS/CD257/DTL/TALL-1/TALL1/THANK/TNFSF20/TNLG7A/ZTNF4	blisibimod		TNFSF13B	Fusion Protein	Detail

Click to check more INN-indexed antibody & protein biosimilar

Pre-made anti-TNFSF13B inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-TNFSF13B benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TNFSF13B mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody Name	Species	Format	Classified by tag	Detail
Anti-TNFSF13B monoclonal antibody	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody	Detail

Multi-species TN13B/ TNFSF13B/ BAFF VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNFSF13B VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products Name	Species	Expression Platform	Detail
TNFSF13B VLP (virus-like particle)	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	Mammalian cell	Products Developing

Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene. BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen; cluster of differentiation 257).

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Detail
TNFSF13B	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF13B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).	Detail

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Pre-made TNFSF13B viral vector in GM Promise-ORF^TM

Cat No.	Products name	NM ID	Species	Type	Detail
vGMLP002206	human TNFSF13B Lentivirus particle	NM_006573	Human	Lentivirus particle	Detail
pGMLP002206	human TNFSF13B Lentivirus plasmid	NM_006573	Human	Lentivirus plasmid	Detail
pGMLV000606	house mouse Tnfsf13b Lentivirus plasmid	NM_033622	House Mouse	Lentivirus plasmid	Detail
pGMLPm000459	mouse Tnfsf13b Lentivirus plasmid	NM_033622	Mouse	Lentivirus plasmid	Detail
vGMLV000606	house mouse Tnfsf13b Lentivirus particle	NM_033622	House Mouse	Lentivirus particle	Detail
vGMLPm000459	mouse Tnfsf13b Lentivirus particle	NM_033622	Mouse	Lentivirus particle	Detail

About Promise-ORF^TM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORF^TM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORF^TM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

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