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It's the GeneMedi's summary page for Target/Biomarker Introduction of CTLA-4,CTLA4. The page also collects GeneMedi's different modalities and formats products for CTLA-4 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CTLA-4 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Target IDGM-T15000
Target NameCTLA-4
Gene ID1493
Gene Official NameCTLA4
Gene AliasALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, INN Index, Immuno-oncology Target


Pre-made CTLA-4-specific INN-index biosimilar (antibody&conjugates)-Cadonilimab, Lorigerlimab, Quavonlimab, Nurulimab, Botensilimab, Tuvonralimab, abatacept, Vudalimab, Ipilimumab, Erfonrilimab, Ticilimumab, Zalifrelimab, Pavunalimab, Tremelimumab

Anti-CTLA-4 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatOrder
GMP-Bios-ab-088Pre-Made Cadonilimab biosimilar, Bispecific Mixed mAb and scFv, Anti-PDCD1/PD-1;CTLA4/CTLA-4 antibody: Anti-CD279/PD1/SLEB2/hPD-1/hPD-l/hSLE1;CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyCadonilimabPDCD1/PD-1; CTLA4/CTLA-4Bispecific Mixed mAb and scFvINN mab
GMP-Bios-ab-679Pre-Made Lorigerlimab biosimilar, Whole mAb, Anti-PDCD1/PD-1;CTLA4/CTLA-4 Antibody: Anti-CD279/PD1/SLEB2/hPD-1/hPD-l/hSLE1;CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyLorigerlimabPDCD1/PD-1;CTLA4/CTLA-4Bispecific Mixed scFv (scFv-CH2-CH3-scFv)INN mab
GMP-Bios-ab-460Pre-Made Quavonlimab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyQuavonlimabCTLA4/CTLA-4Whole mAbINN mab
GMP-Bios-ab-382Pre-Made Nurulimab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyNurulimabCTLA4/CTLA-4Whole mAbINN mab
GMP-Bios-ab-078Pre-Made Botensilimab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyBotensilimabCTLA4/CTLA-4Whole mAbINN mab
GMP-Bios-ab-704Pre-Made Tuvonralimab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyTuvonralimabCTLA4/CTLA-4Whole mAbINN mab
GMP-Bios-INN-712Pre-Made Abatacept Biosimilar, Fusion Protein targeting CTLA4/CTLA-4 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3abataceptCTLA-4Fusion ProteinINN mab
GMP-Bios-ab-631Pre-Made Vudalimab biosimilar, Bispecific Mixed mAb and scFv, Anti-CTLA4/CTLA-4;PDCD1/PD-1 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3;CD279/SLEB2/hPD-1/hPD-l/hSLE1 therapeutic antibodyVudalimabCTLA4/CTLA-4;PDCD1/PD-1Bispecific Mixed mAb and scFvINN mab
GMP-Bios-ab-277Pre-Made Ipilimumab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyIpilimumabCTLA4/CTLA-4Whole mAbINN mab
GMP-Bios-ab-194Pre-Made Erfonrilimab biosimilar, Bispecific Single Domains (VH-VH'-CH), Anti-CD274/PD-L1;CTLA4/CTLA-4 Antibody: Anti-B7-H/B7H1/PDCD1L1/PDCD1LG1;CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyErfonrilimabCD274/PD-L1;CTLA4/CTLA-4Bispecific Single Domains (VH-VH'-CH)INN mab
GMP-Bios-ab-569Pre-Made Ticilimumab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyTicilimumabtremelimumabCTLA4/CTLA-4Whole mAbINN mab
GMP-Bios-ab-636Pre-Made Zalifrelimab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyZalifrelimabCTLA4/CTLA-4Whole mAbINN mab
GMP-Bios-ab-432Pre-Made Pavunalimab biosimilar, Bispecific Mixed mAb and scFv, Anti-LAG3;CTLA4/CTLA-4 Antibody: Anti-CD223;CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyPavunalimabbavunalimabLAG3;CTLA4/CTLA-4Bispecific Mixed mAb and scFvINN mab
GMP-Bios-ab-595Pre-Made Tremelimumab biosimilar, Whole mAb, Anti-CTLA4/CTLA-4 Antibody: Anti-CD/GSE/GRD4/ALPS5/CD152/IDDM12/CELIAC3 therapeutic antibodyTremelimumabTicilimumabCTLA4/CTLA-4Whole mAbINN mab



Pre-made anti-CTLA-4 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-CTLA-4 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CTLA-4 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.Antibody NameFormatClassified by tagOrder
GM-Tg-hg-T15000-AbAnti-CTLA-4/CTLA4 monoclonal antibodymabBiofunctional antibody, Therapeutics Target antibodymonoclonal antibody.




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