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Anti-CTLA4/ CTLA-4/ ALPS5 monoclonal antibody
Anti-CTLA4/ CTLA-4/ ALPS5 antibody for FACS & in-vivo assay
Go to CTLA-4/CTLA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T15000-Ab-1/ GM-Tg-hg-T15000-Ab-2 | Anti-Human CTLA-4/CTLA4 monoclonal antibody | Human |
| GM-Tg-rg-T15000-Ab-1/ GM-Tg-rg-T15000-Ab-2 | Anti-Rat CTLA-4/CTLA4 monoclonal antibody | Rat |
| GM-Tg-mg-T15000-Ab-1/ GM-Tg-mg-T15000-Ab-2 | Anti-Mouse CTLA-4/CTLA4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T15000-Ab-1/ GM-Tg-cynog-T15000-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CTLA-4/CTLA4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T15000-Ab-1/ GM-Tg-felg-T15000-Ab-2 | Anti-Feline CTLA-4/CTLA4 monoclonal antibody | Feline |
| GM-Tg-cang-T15000-Ab-1/ GM-Tg-cang-T15000-Ab-2 | Anti-Canine CTLA-4/CTLA4 monoclonal antibody | Canine |
| GM-Tg-bovg-T15000-Ab-1/ GM-Tg-bovg-T15000-Ab-2 | Anti-Bovine CTLA-4/CTLA4 monoclonal antibody | Bovine |
| GM-Tg-equg-T15000-Ab-1/ GM-Tg-equg-T15000-Ab-2 | Anti-Equine CTLA-4/CTLA4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T15000-Ab-1/ GM-Tg-hg-T15000-Ab-2; GM-Tg-rg-T15000-Ab-1/ GM-Tg-rg-T15000-Ab-2; GM-Tg-mg-T15000-Ab-1/ GM-Tg-mg-T15000-Ab-2; GM-Tg-cynog-T15000-Ab-1/ GM-Tg-cynog-T15000-Ab-2; GM-Tg-felg-T15000-Ab-1/ GM-Tg-felg-T15000-Ab-2; GM-Tg-cang-T15000-Ab-1/ GM-Tg-cang-T15000-Ab-2; GM-Tg-bovg-T15000-Ab-1/ GM-Tg-bovg-T15000-Ab-2; GM-Tg-equg-T15000-Ab-1/ GM-Tg-equg-T15000-Ab-2 |
| Products Name | Anti-CTLA-4/CTLA4 monoclonal antibody |
| Format | mab |
| Target Name | CTLA-4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CTLA-4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T15000 |
| Target Name | CTLA-4 |
| Gene ID | 1493,12477,63835,705673,403696,493743,281732,100067931 |
| Gene Symbol and Synonyms | ALPS5,CD,CD152,CELIAC3,CTLA-4,CTLA4,GRD4,GSE,IDDM12,Ly-56,sCTLA4 |
| Uniprot Accession | P16410,Q9XSI1 |
| Uniprot Entry Name | CTLA4_HUMAN,CTLA4_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Hepatitis - type 1 autoimmune, Grave's Disease, Autoimmune thyroid diseases, asthma |
| Gene Ensembl | ENSG00000163599 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: CTLA-4, gene name: CTLA4, also named as ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12. This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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