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It's the GeneMedi's summary page for Target/Biomarker Introduction of PCSK9. The page also collects GeneMedi's different modalities and formats products for PCSK9 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the PCSK9 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Target IDGM-T62206
Target NamePCSK9
Gene ID255738
Gene Official NamePCSK9
Gene AliasFH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, INN Index


Pre-made PCSK9-specific INN-index biosimilar (antibody&conjugates)-Bococizumab, Alirocumab, Ebronucimab, Ralpancizumab, Lodelcizumab, Ongericimab, Recaticimab, Tafolecimab, Evolocumab, Frovocimab, lerodalcibep

Anti-PCSK9 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatOrder
GMP-Bios-ab-077Pre-Made Bococizumab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyBococizumabPCSK9Whole mAbINN mab
GMP-Bios-ab-016Pre-Made Alirocumab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyAlirocumabPCSK9Whole mAbINN mab
GMP-Bios-ab-163Pre-Made Ebronucimab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyEbronucimabPCSK9Whole mAbINN mab
GMP-Bios-ab-467Pre-Made Ralpancizumab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyRalpancizumabPCSK9Whole mAbINN mab
GMP-Bios-ab-318Pre-Made Lodelcizumab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyLodelcizumabPCSK9Whole mAbINN mab
GMP-Bios-ab-403Pre-Made Ongericimab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyOngericimabPCSK9Whole mAbINN mab
GMP-Bios-ab-473Pre-Made Recaticimab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyRecaticimabPCSK9Whole mAbINN mab
GMP-Bios-ab-544Pre-Made Tafolecimab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyTafolecimabPCSK9Whole mAbINN mab
GMP-Bios-ab-202Pre-Made Evolocumab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyEvolocumabPCSK9Whole mAbINN mab
GMP-Bios-ab-224Pre-Made Frovocimab biosimilar, Whole mAb, Anti-PCSK9 Antibody: Anti-FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9 therapeutic antibodyFrovocimabPCSK9Whole mAbINN mab
GMP-Bios-INN-890Pre-Made Lerodalcibep Biosimilar, Fusion Protein targeting PCSK9 fused with ALB (albumin, human serum albumin, HSA): Recombinant therapeutic protein targeting FH3/FHCL3/HCHOLA3/LDLCQ1/NARC-1/NARC1/PC9lerodalcibepPCSK9Fusion ProteinINN mab



Pre-made anti-PCSK9 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-PCSK9 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-PCSK9 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.Antibody NameFormatClassified by tagOrder
GM-Tg-hg-T62206-AbAnti-PCSK9 monoclonal antibodymabBiofunctional antibody, Therapeutics Target antibodymonoclonal antibody.




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