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Anti-PCSK9/ FH3/ HCHOLA3 monoclonal antibody
Anti-PCSK9/ FH3/ HCHOLA3 antibody for FACS & in-vivo assay
Go to PCSK9/PCSK9 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T62206-Ab-1/ GM-Tg-hg-T62206-Ab-2 | Anti-Human PCSK9 monoclonal antibody | Human |
| GM-Tg-rg-T62206-Ab-1/ GM-Tg-rg-T62206-Ab-2 | Anti-Rat PCSK9 monoclonal antibody | Rat |
| GM-Tg-mg-T62206-Ab-1/ GM-Tg-mg-T62206-Ab-2 | Anti-Mouse PCSK9 monoclonal antibody | Mouse |
| GM-Tg-cynog-T62206-Ab-1/ GM-Tg-cynog-T62206-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCSK9 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T62206-Ab-1/ GM-Tg-felg-T62206-Ab-2 | Anti-Feline PCSK9 monoclonal antibody | Feline |
| GM-Tg-cang-T62206-Ab-1/ GM-Tg-cang-T62206-Ab-2 | Anti-Canine PCSK9 monoclonal antibody | Canine |
| GM-Tg-bovg-T62206-Ab-1/ GM-Tg-bovg-T62206-Ab-2 | Anti-Bovine PCSK9 monoclonal antibody | Bovine |
| GM-Tg-equg-T62206-Ab-1/ GM-Tg-equg-T62206-Ab-2 | Anti-Equine PCSK9 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T62206-Ab-1/ GM-Tg-hg-T62206-Ab-2; GM-Tg-rg-T62206-Ab-1/ GM-Tg-rg-T62206-Ab-2; GM-Tg-mg-T62206-Ab-1/ GM-Tg-mg-T62206-Ab-2; GM-Tg-cynog-T62206-Ab-1/ GM-Tg-cynog-T62206-Ab-2; GM-Tg-felg-T62206-Ab-1/ GM-Tg-felg-T62206-Ab-2; GM-Tg-cang-T62206-Ab-1/ GM-Tg-cang-T62206-Ab-2; GM-Tg-bovg-T62206-Ab-1/ GM-Tg-bovg-T62206-Ab-2; GM-Tg-equg-T62206-Ab-1/ GM-Tg-equg-T62206-Ab-2 |
| Products Name | Anti-PCSK9 monoclonal antibody |
| Format | mab |
| Target Name | PCSK9 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PCSK9 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T62206 |
| Target Name | PCSK9 |
| Gene ID | 255738,100102,298296,717147,100147049 |
| Gene Symbol and Synonyms | FH3,FHCL3,HCHOLA3,LDLCQ1,NARC-1,NARC1,PC9,PCSK9 |
| Uniprot Accession | Q8NBP7,P59996,A8T666 |
| Uniprot Entry Name | PCSK9_HUMAN,PCSK9_MACMU,PCSK9_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000169174 |
| Target Classification | N/A |
The target: PCSK9, gene name: PCSK9, also named as FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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