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Human PCSK9/FH3/ FHCL3 ORF/cDNA clone-Lentivirus plasmid (NM_174936.3)
Pre-made Human PCSK9/FH3/ FHCL3 Lentiviral expression plasmid for PCSK9 lentivirus packaging, PCSK9 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.
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Product information
| Catalog No. | Product Name | Plasmid Grade | Plasmid quantity |
|---|---|---|---|
| pGMLV000015 | Human PCSK9 Lentivirus plasmid | Research Grade | 10mg, 50mg, 100mg, 500mg, >1g |
| GMP-like Grade | 10mg, 50mg, 100mg, 500mg, >1g | ||
| High Quality (HQ) Grade | |||
| Seed | 5ug |
Product Description
| Catalog ID | pGMLV000015 |
| Gene Name | PCSK9 |
| Accession Number | NM_174936.3 |
| Gene ID | 255738 |
| Species | Human |
| Product Type | Lentivirus plasmid (overexpression) |
| Insert Length | 2079 bp |
| Gene Alias | FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9 |
| Fluorescent Reporter | ZsGreen |
| Mammalian Cell Selection | Puromyocinmyocin |
| Fusion Tag | 3xflag (C-Terminal) |
| Promoter | CMV |
| Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T62206 |
| Target Name | PCSK9 |
| Gene ID | 255738, 100102, 717147, 298296, 102152231, 100147049 |
| Gene Symbol and Synonyms | FH3,FHCL3,HCHOLA3,LDLCQ1,NARC-1,NARC1,PC9,PCSK9 |
| Uniprot Accession | Q8NBP7 |
| Uniprot Entry Name | PCSK9_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000169174 |
| Target Classification | Not Available |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.
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