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It's the GeneMedi's summary page for Target/Biomarker Introduction of FLT-1,FLT1. The page also collects GeneMedi's different modalities and formats products for FLT-1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the FLT-1 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Target IDGM-T63966
Target NameFLT-1
Gene ID2321
Gene Official NameFLT1
Gene AliasFLT, FLT-1, VEGFR-1, VEGFR1
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, INN Index, Cytokine Target, Immuno-oncology Target


Pre-made FLT-1-specific INN-index biosimilar (antibody&conjugates)-Icrucumab

Anti-FLT-1 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatOrder
GMP-Bios-ab-259Pre-Made Icrucumab biosimilar, Whole mAb, Anti-FLT1/FLT-1 Antibody: Anti-VEGFR-1/VEGFR1 therapeutic antibodyIcrucumabFLT1/FLT-1Whole mAbINN mab



Pre-made anti-FLT-1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-FLT-1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-FLT-1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.Antibody NameFormatClassified by tagOrder
GM-Tg-hg-T63966-AbAnti-FLT-1/FLT1 monoclonal antibodymabBiofunctional antibody, Therapeutics Target antibody, Cytokine antibodymonoclonal antibody.




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