IFNG: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of IFNG. The page also collects GeneMedi's different modalities and formats products for IFNG in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the IFNG target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
|Gene Symbol and Synonyms||If2f,IFG,IFI,IFN-g,IFN-gamma,IFNG,IFNG2,IMD69|
|Uniprot Entry Name||IFNG_HUMAN,IFNG_MACMU,IFNG_RAT,IFNG_FELCA,IFNG_CANLF,IFNG_BOVIN,IFNG_HORSE|
|Protein Sub-location||Secreted Protein/Potential Cytokines|
|Category||Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index, Cytokine Target|
|Target Classification||Checkpoint-Immuno Oncology|
Pre-made IFNG-specific INN-index biosimilar (antibody&conjugates)
Anti-IFNG therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
|Cat No.||Products Name (INN Index)||INN Name||Previous Name||Target||Format||Detail|
|GMP-Bios-ab-175||Pre-Made Emapalumab biosimilar, Whole mAb, Anti-IFNG Antibody: Anti-IFG/IFI/IMD69 therapeutic antibody||Emapalumab||IFNG||Whole mAb||Detail|
|GMP-Bios-ab-219||Pre-Made Fontolizumab biosimilar, Whole mAb, Anti-IFNG Antibody: Anti-IFG/IFI/IMD69 therapeutic antibody||Fontolizumab||IFNG||Whole mAb||Detail|
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-IFNG inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-IFNG benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-IFNG mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
|Antibody Name||Species||Format||Classified by tag||Detail|
|Anti-IFNG monoclonal antibody||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||mab||FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody||Detail|
Recombinant multi-species IFNG/ IFG/ IFI protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IFNG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
|Products Name||Species||Expression Platform||Detail|
|IFNG protein||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||Mammalian cell||Detail|
Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse interferon, gamma (IFNG) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Interferon gamma (IFN??) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. It was also shown to be produced in human lymphocytes. or tuberculin-sensitized mouse peritoneal lymphocytes challenged with Mantoux test (PPD); the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFN?? protein is encoded by the IFNG gene.
|Target||Species||Antigen Product Name||Bioactivity validation of Antigen||Antibody Product Name||Bioactivity validation of Antibodies||Detail|
|IFNG||Human, Cynomolgus/Rhesus macaque, rat, mouse||interferon, gamma (IFNG) protein||Affintiy&bioactivity validated by ELISA, cell culture validated||Anti-IFNG monoclonal antibody||Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).||Detail|
Click to check more Cytokine Products
Pre-made IFNG viral vector in GM Promise-ORFTM
|Cat No.||Products name||NM ID||Species||Type||Detail|
|vGMAD000575||human IFNG Adenovirus particle||NM_000619.3||Human||Adenovirus particle||Detail|
|pGMAP000297||Human IFNG Adenovirus plasmid||BC070256||Human||Adenovirus plasmid||Detail|
|vGMLP000461||human IFNG Lentivirus particle||NM_000619||Human||Lentivirus particle||Detail|
|vGMAP000297||Human IFNG Adenovirus particle||BC070256||Human||Adenovirus particle||Detail|
|pGMAD000575||human IFNG Adenovirus plasmid||NM_000619.3||Human||Adenovirus plasmid||Detail|
|pGMLP000461||human IFNG Lentivirus plasmid||NM_000619||Human||Lentivirus plasmid||Detail|
|pGMLPm000110||mouse Ifng Lentivirus plasmid||NM_008337||Mouse||Lentivirus plasmid||Detail|
|vGMLPm000110||mouse Ifng Lentivirus particle||NM_008337||Mouse||Lentivirus particle||Detail|
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.