GFRA3: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of GFRA3. The page also collects GeneMedi's different modalities and formats products for GFRA3 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the GFRA3 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

Target ID	GM-T92042
Target Name	GFRA3
Gene ID	2676,14587,84422,714050,481527,101086693,540009,100072589
Gene Symbol and Synonyms	GDNFR3,GFRA3,GFRalpha3
Uniprot Accession	O60609
Uniprot Entry Name	GFRA3_HUMAN
Protein Sub-location	Transmembrane Protein
Category	Therapeutics Target, INN Index, Cytokine Target
Disease	N/A
Gene Ensembl	ENSG00000146013
Target Classification	N/A

Pre-made GFRA3-specific INN-index biosimilar (antibody&conjugates)

Anti-GFRA3 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.	Products Name (INN Index)	INN Name	Previous Name	Target	Format	Detail
GMP-Bios-ab-361	Pre-Made Nadecnemab biosimilar, Whole mAb, Anti-GFRA3 Antibody: Anti-GDNFR3 therapeutic antibody	Nadecnemab		GFRA3	Whole mAb	Detail

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Pre-made anti-GFRA3 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-GFRA3 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-GFRA3 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody Name	Species	Format	Classified by tag	Detail
Anti-GFRA3 monoclonal antibody	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody	Detail

Multi-species GFRA3/ GDNFR3 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GFRA3 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products Name	Species	Expression Platform	Detail
GFRA3 VLP (virus-like particle)	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	Mammalian cell	Products Developing

Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse GDNF family receptor alpha 3 (GFRA3) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

GDNF family receptor alpha-3 (GFR??3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene. The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Detail
GFRA3	Human, Cynomolgus/Rhesus macaque, rat, mouse	GDNF family receptor alpha 3 (GFRA3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GFRA3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).	Detail

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Pre-made GFRA3 viral vector in GM Promise-ORF^TM

Cat No.	Products name	NM ID	Species	Type	Detail
pGMLP001514	human GFRA3 Lentivirus plasmid	NM_001496	Human	Lentivirus plasmid	Detail
vGMLP001514	human GFRA3 Lentivirus particle	NM_001496	Human	Lentivirus particle	Detail
pGMLPm005280	mouse Gfra3 Lentivirus plasmid	NM_010280.4	Mouse	Lentivirus plasmid	Detail
vGMLPm005280	mouse Gfra3 Lentivirus particle	NM_010280.4	Mouse	Lentivirus particle	Detail

About Promise-ORF^TM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORF^TM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORF^TM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.