Human RSPO1/CRISTIN3/RSPO ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_001038633.3)

Cat. No.: pGMAAV000008
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human RSPO1/CRISTIN3/RSPO Adeno-associated virus expression plasmid (ITR-vector) for RSPO1 AAV packaging, RSPO1 AAV production.The purified Human RSPO1/CRISTIN3/RSPO AAV particle serves as an invaluable asset for in-depth in vivo RSPO1 studies, mechanism of action (MOA) research, and the evolution of RSPO1-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV000008
Gene Name RSPO1
Accession Number NM_001038633.3
Gene ID 284654
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 792 bp
Gene Alias CRISTIN3,RSPO
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGCGGCTTGGGCTGTGTGTGGTGGCCCTGGTTCTGAGCTGGACGCACCTCACCATCAGCAGCCGGGGGATCAAGGGGAAAAGGCAGAGGCGGATCAGTGCCGAGGGGAGCCAGGCCTGTGCCAAAGGCTGTGAGCTCTGCTCTGAAGTCAACGGCTGCCTCAAGTGCTCACCCAAGCTGTTCATCCTGCTGGAGAGGAACGACATCCGCCAGGTGGGCGTCTGCTTGCCGTCCTGCCCACCTGGATACTTCGACGCCCGCAACCCCGACATGAACAAGTGCATCAAATGCAAGATCGAGCACTGTGAGGCCTGCTTCAGCCATAACTTCTGCACCAAGTGTAAGGAGGGCTTGTACCTGCACAAGGGCCGCTGCTATCCAGCTTGTCCCGAGGGCTCCTCAGCTGCCAATGGCACCATGGAGTGCAGTAGTCCTGCGCAATGTGAAATGAGCGAGTGGTCTCCGTGGGGGCCCTGCTCCAAGAAGCAGCAGCTCTGTGGTTTCCGGAGGGGCTCCGAGGAGCGGACACGCAGGGTGCTACATGCCCCTGTGGGGGACCATGCTGCCTGCTCTGACACCAAGGAGACCCGGAGGTGCACAGTGAGGAGAGTGCCGTGTCCTGAGGGGCAGAAGAGGAGGAAGGGAGGCCAGGGCCGGCGGGAGAATGCCAACAGGAACCTGGCCAGGAAGGAGAGCAAGGAGGCGGGTGCTGGCTCTCGAAGACGCAAGGGGCAGCAACAGCAGCAGCAGCAAGGGACAGTGGGGCCACTCACATCTGCAGGGCCTGCCTAG
ORF Protein Sequence MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSRRRKGQQQQQQQGTVGPLTSAGPA

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T91023-Ab Anti-RSPO1/ CRISTIN3/ RSPO functional antibody
    Target Antigen GM-Tg-g-T91023-Ag RSPO1 protein
    ORF Viral Vector pGMLP003166 Human RSPO1 Lentivirus plasmid
    ORF Viral Vector pGMLV002698 Human RSPO1 Lentivirus plasmid
    ORF Viral Vector pGMAAV000008 Human RSPO1 Adeno-associate virus(AAV) plasmid
    ORF Viral Vector vGMLP003166 Human RSPO1 Lentivirus particle
    ORF Viral Vector vGMLV002698 Human RSPO1 Lentivirus particle
    ORF Viral Vector vGMAAV000008 Human RSPO1 Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-T91023
    Target Name RSPO1
    Gene ID 284654, 192199, 713976, 313589, 101091033, 608179, 511675, 100054745
    Gene Symbol and Synonyms CRISTIN3,R-spondin,RGD1565558,RSPO,RSPO1,Rspondin
    Uniprot Accession Q2MKA7
    Uniprot Entry Name RSPO1_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000169218
    Target Classification Not Available

    This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]



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