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Anti-RSPO1/ CRISTIN3/ RSPO functional antibody
Anti-RSPO1/ CRISTIN3/ RSPO functional antibody for cell culture, ELISA & in-vivo assay
Go to RSPO1/RSPO1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T91023-Ab-1/ GM-Tg-hg-T91023-Ab-2 | Anti-Human RSPO1 monoclonal antibody | Human |
| GM-Tg-rg-T91023-Ab-1/ GM-Tg-rg-T91023-Ab-2 | Anti-Rat RSPO1 monoclonal antibody | Rat |
| GM-Tg-mg-T91023-Ab-1/ GM-Tg-mg-T91023-Ab-2 | Anti-Mouse RSPO1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T91023-Ab-1/ GM-Tg-cynog-T91023-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RSPO1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T91023-Ab-1/ GM-Tg-felg-T91023-Ab-2 | Anti-Feline RSPO1 monoclonal antibody | Feline |
| GM-Tg-cang-T91023-Ab-1/ GM-Tg-cang-T91023-Ab-2 | Anti-Canine RSPO1 monoclonal antibody | Canine |
| GM-Tg-bovg-T91023-Ab-1/ GM-Tg-bovg-T91023-Ab-2 | Anti-Bovine RSPO1 monoclonal antibody | Bovine |
| GM-Tg-equg-T91023-Ab-1/ GM-Tg-equg-T91023-Ab-2 | Anti-Equine RSPO1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T91023-Ab-1/ GM-Tg-hg-T91023-Ab-2; GM-Tg-rg-T91023-Ab-1/ GM-Tg-rg-T91023-Ab-2; GM-Tg-mg-T91023-Ab-1/ GM-Tg-mg-T91023-Ab-2; GM-Tg-cynog-T91023-Ab-1/ GM-Tg-cynog-T91023-Ab-2; GM-Tg-felg-T91023-Ab-1/ GM-Tg-felg-T91023-Ab-2; GM-Tg-cang-T91023-Ab-1/ GM-Tg-cang-T91023-Ab-2; GM-Tg-bovg-T91023-Ab-1/ GM-Tg-bovg-T91023-Ab-2; GM-Tg-equg-T91023-Ab-1/ GM-Tg-equg-T91023-Ab-2 |
| Products Name | Anti-RSPO1 monoclonal antibody |
| Format | mab |
| Target Name | RSPO1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RSPO1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T91023-Ag-1 | Recombinant multi-species RSPO1/ CRISTIN3/ RSPO protein |
| ORF Viral Vector | vGMLP003166 | human RSPO1 Lentivirus particle |
| ORF Viral Vector | vGMAAV000008 | human RSPO1 AAV particle |
| ORF Viral Vector | pGMAAV000008 | human RSPO1 AAV plasmid |
| ORF Viral Vector | pGMLP003166 | human RSPO1 Lentivirus plasmid |
| ORF Viral Vector | pGMLP001150 | house mouse Rspo1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000589 | mouse Rspo1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001150 | house mouse Rspo1 Lentivirus particle |
| ORF Viral Vector | vGMLPm000589 | mouse Rspo1 Lentivirus particle |
Target information
| Target ID | GM-T91023 |
| Target Name | RSPO1 |
| Gene ID | 284654,192199,313589,713976,608179,101091033,511675,100054745 |
| Gene Symbol and Synonyms | CRISTIN3,R-spondin,RGD1565558,RSPO,RSPO1,Rspondin |
| Uniprot Accession | Q2MKA7 |
| Uniprot Entry Name | RSPO1_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000169218 |
| Target Classification | N/A |
The target: RSPO1, gene name: RSPO1, also named as CRISTIN3, RSPO. This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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