RSPO1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of RSPO1. The page also collects GeneMedi's different modalities and formats products for RSPO1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the RSPO1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Target ID | GM-T91023 |
Target Name | RSPO1 |
Gene ID | 284654,192199,313589,713976,608179,101091033,511675,100054745 |
Gene Symbol and Synonyms | CRISTIN3,R-spondin,RGD1565558,RSPO,RSPO1,Rspondin |
Uniprot Accession | Q2MKA7 |
Uniprot Entry Name | RSPO1_HUMAN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000169218 |
Target Classification | N/A |
Pre-made anti-RSPO1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-RSPO1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-RSPO1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-RSPO1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Recombinant multi-species RSPO1/ CRISTIN3/ RSPO protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RSPO1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
RSPO1 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made RSPO1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMLP003166 | human RSPO1 Lentivirus particle | NM_001242908 | Human | Lentivirus particle | Detail |
vGMAAV000008 | human RSPO1 AAV particle | NM_001038633.3 | Human | AAV particle | Detail |
pGMAAV000008 | human RSPO1 AAV plasmid | NM_001038633.3 | Human | AAV plasmid | Detail |
pGMLP003166 | human RSPO1 Lentivirus plasmid | NM_001242908 | Human | Lentivirus plasmid | Detail |
pGMLP001150 | house mouse Rspo1 Lentivirus plasmid | NM_138683.2 | House Mouse | Lentivirus plasmid | Detail |
pGMLPm000589 | mouse Rspo1 Lentivirus plasmid | NM_138683 | Mouse | Lentivirus plasmid | Detail |
vGMLP001150 | house mouse Rspo1 Lentivirus particle | NM_138683.2 | House Mouse | Lentivirus particle | Detail |
vGMLPm000589 | mouse Rspo1 Lentivirus particle | NM_138683 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.