Human MAPK8/JNK/ JNK-46 ORF/cDNA clone-Adenovirus plasmid (NM_001323302.1)

Product information

Catalog No.	Product Name	Plasmid Grade	Plasmid quantity
pGMAD000121	Human MAPK8 Adenovirus plasmid	Research Grade	10mg, 50mg, 100mg, 500mg, >1g
		GMP-like Grade	10mg, 50mg, 100mg, 500mg, >1g
		High Quality (HQ) Grade
		Seed	5ug

Product Description

Catalog ID	pGMAD000121
Gene Name	MAPK8
Accession Number	NM_001323302.1
Gene ID	5599
Species	Human
Product Type	Adenovirus plasmid (overexpression)
Insert Length	1155 bp
Gene Alias	JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Fluorescent Reporter	EGFP
Mammalian Cell Selection
Fusion Tag	3xflag (C-Terminal)
Promoter	CMV
Resistance	Amplicin

Reference

Data / case study

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Associated products

Category	Cat No.	Products Name
Target Antibody	GM-Tg-g-T40097-Ab	Anti-JNK1 monoclonal antibody
Target Antigen	GM-Tg-g-T40097-Ag	JNK1/MAPK8 protein
ORF Viral Vector	pGMAD000121	Human MAPK8 Adenovirus plasmid
ORF Viral Vector	pGMPC000125	Human MAPK8 Mammalian (Non-Viral Vector) plasmid
ORF Viral Vector	pGMLP-SPh-013	Human MAPK8 Lentivirus plasmid
ORF Viral Vector	pGMLP-SPh-056	Human MAPK8 Lentivirus plasmid
ORF Viral Vector	pGMAP-SPh-153	Human MAPK8 Adenovirus plasmid
ORF Viral Vector	pGMAP-SPh-196	Human MAPK8 Adenovirus plasmid
ORF Viral Vector	vGMAD000121	Human MAPK8 Adenovirus particle
ORF Viral Vector	vGMLP-SPh-013	Human MAPK8 Lentivirus particle
ORF Viral Vector	vGMLP-SPh-056	Human MAPK8 Lentivirus particle
ORF Viral Vector	vGMAP-SPh-153	Human MAPK8 Adenovirus particle
ORF Viral Vector	vGMAP-SPh-196	Human MAPK8 Adenovirus particle

Target information

Target ID	GM-T40097
Target Name	JNK1
Gene ID	5599, 26419, 711115, 116554, 101091310, 477746, 539941, 100051798
Gene Symbol and Synonyms	JNK,JNK-46,JNK1,JNK1A2,JNK21B1/2,MAPK8,PRKM8,SAPK1,SAPK1c
Uniprot Accession	P45983
Uniprot Entry Name	MK08_HUMAN
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	Cancer
Gene Ensembl	ENSG00000107643
Target Classification	Kinase, Tumor-associated antigen (TAA)

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

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