Anti-JNK1 monoclonal antibody
Pre-made anti-JNK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T40097-Ab-1/ GM-Tg-hg-T40097-Ab-2 | Anti-Human JNK1/MAPK8 monoclonal antibody | Human |
GM-Tg-rg-T40097-Ab-1/ GM-Tg-rg-T40097-Ab-2 | Anti-Rat JNK1/MAPK8 monoclonal antibody | Rat |
GM-Tg-mg-T40097-Ab-1/ GM-Tg-mg-T40097-Ab-2 | Anti-Mouse JNK1/MAPK8 monoclonal antibody | Mouse |
GM-Tg-cynog-T40097-Ab-1/ GM-Tg-cynog-T40097-Ab-2 | Anti-Cynomolgus/ Rhesus macaque JNK1/MAPK8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T40097-Ab-1/ GM-Tg-felg-T40097-Ab-2 | Anti-Feline JNK1/MAPK8 monoclonal antibody | Feline |
GM-Tg-cang-T40097-Ab-1/ GM-Tg-cang-T40097-Ab-2 | Anti-Canine JNK1/MAPK8 monoclonal antibody | Canine |
GM-Tg-bovg-T40097-Ab-1/ GM-Tg-bovg-T40097-Ab-2 | Anti-Bovine JNK1/MAPK8 monoclonal antibody | Bovine |
GM-Tg-equg-T40097-Ab-1/ GM-Tg-equg-T40097-Ab-2 | Anti-Equine JNK1/MAPK8 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T40097-Ab-1/ GM-Tg-hg-T40097-Ab-2; GM-Tg-rg-T40097-Ab-1/ GM-Tg-rg-T40097-Ab-2; GM-Tg-mg-T40097-Ab-1/ GM-Tg-mg-T40097-Ab-2; GM-Tg-cynog-T40097-Ab-1/ GM-Tg-cynog-T40097-Ab-2; GM-Tg-felg-T40097-Ab-1/ GM-Tg-felg-T40097-Ab-2; GM-Tg-cang-T40097-Ab-1/ GM-Tg-cang-T40097-Ab-2; GM-Tg-bovg-T40097-Ab-1/ GM-Tg-bovg-T40097-Ab-2; GM-Tg-equg-T40097-Ab-1/ GM-Tg-equg-T40097-Ab-2 |
Products Name | Anti-JNK1/MAPK8 monoclonal antibody |
Format | mab |
Target Name | JNK1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-JNK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T40097-Ag-1 | Recombinant multi-species MK08/ JNK1/ MAPK8 protein |
ORF Viral Vector | pGMAD000121 | human MAPK8 Adenovirus plasmid |
ORF Viral Vector | vGMAD000121 | human MAPK8 Adenovirus particle |
Target information
Target ID | GM-T40097 |
Target Name | JNK1 |
Gene ID | 5599,26419,116554,711115,477746,101091310,539941,100051798 |
Gene Symbol and Synonyms | JNK,JNK-46,JNK1,JNK1A2,JNK21B1/2,MAPK8,PRKM8,SAPK1,SAPK1c |
Uniprot Accession | P45983,P49185 |
Uniprot Entry Name | MK08_HUMAN,MK08_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000107643 |
Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: JNK1, gene name: MAPK8, also named as JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.