Anti-JNK1 monoclonal antibody

Pre-made anti-JNK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to JNK1/MAPK8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T40097-Ab-1/ GM-Tg-hg-T40097-Ab-2Anti-Human JNK1/MAPK8 monoclonal antibodyHuman
GM-Tg-rg-T40097-Ab-1/ GM-Tg-rg-T40097-Ab-2Anti-Rat JNK1/MAPK8 monoclonal antibodyRat
GM-Tg-mg-T40097-Ab-1/ GM-Tg-mg-T40097-Ab-2Anti-Mouse JNK1/MAPK8 monoclonal antibodyMouse
GM-Tg-cynog-T40097-Ab-1/ GM-Tg-cynog-T40097-Ab-2Anti-Cynomolgus/ Rhesus macaque JNK1/MAPK8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T40097-Ab-1/ GM-Tg-felg-T40097-Ab-2Anti-Feline JNK1/MAPK8 monoclonal antibodyFeline
GM-Tg-cang-T40097-Ab-1/ GM-Tg-cang-T40097-Ab-2Anti-Canine JNK1/MAPK8 monoclonal antibodyCanine
GM-Tg-bovg-T40097-Ab-1/ GM-Tg-bovg-T40097-Ab-2Anti-Bovine JNK1/MAPK8 monoclonal antibodyBovine
GM-Tg-equg-T40097-Ab-1/ GM-Tg-equg-T40097-Ab-2Anti-Equine JNK1/MAPK8 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T40097-Ab-1/ GM-Tg-hg-T40097-Ab-2; GM-Tg-rg-T40097-Ab-1/ GM-Tg-rg-T40097-Ab-2;
GM-Tg-mg-T40097-Ab-1/ GM-Tg-mg-T40097-Ab-2; GM-Tg-cynog-T40097-Ab-1/ GM-Tg-cynog-T40097-Ab-2;
GM-Tg-felg-T40097-Ab-1/ GM-Tg-felg-T40097-Ab-2; GM-Tg-cang-T40097-Ab-1/ GM-Tg-cang-T40097-Ab-2;
GM-Tg-bovg-T40097-Ab-1/ GM-Tg-bovg-T40097-Ab-2; GM-Tg-equg-T40097-Ab-1/ GM-Tg-equg-T40097-Ab-2
Products NameAnti-JNK1/MAPK8 monoclonal antibody
Formatmab
Target NameJNK1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-JNK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T40097-Ag-1Recombinant multi-species MK08/ JNK1/ MAPK8 protein
    ORF Viral VectorpGMAD000121human MAPK8 Adenovirus plasmid
    ORF Viral VectorvGMAD000121human MAPK8 Adenovirus particle


    Target information

    Target IDGM-T40097
    Target NameJNK1
    Gene ID5599,26419,116554,711115,477746,101091310,539941,100051798
    Gene Symbol and SynonymsJNK,JNK-46,JNK1,JNK1A2,JNK21B1/2,MAPK8,PRKM8,SAPK1,SAPK1c
    Uniprot AccessionP45983,P49185
    Uniprot Entry NameMK08_HUMAN,MK08_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000107643
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: JNK1, gene name: MAPK8, also named as JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.