Recombinant multi-species MK08/ JNK1/ MAPK8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JNK1/MAPK8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: JNK1, gene name: MAPK8, also named as JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T40097-Ag-1	Human JNK1/MAPK8 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T40097-Ag-1	Rat JNK1/MAPK8 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T40097-Ag-1	Mouse JNK1/MAPK8 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T40097-Ag-1	Cynomolgus/ Rhesus macaque JNK1/MAPK8 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T40097-Ag-1	Feline JNK1/MAPK8 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T40097-Ag-1	Canine JNK1/MAPK8 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T40097-Ag-1	Bovine JNK1/MAPK8 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T40097-Ag-1	Equine JNK1/MAPK8 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T40097-Ag, GM-Tg-rg-T40097-Ag, GM-Tg-mg-T40097-Ag, GM-Tg-cynog-T40097-Ag, GM-Tg-felg-T40097-Ag, GM-Tg-cang-T40097-Ag, GM-Tg-bovg-T40097-Ag, GM-Tg-equg-T40097-Ag-1
Products Name	JNK1/MAPK8 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	JNK1
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JNK1/MAPK8 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.