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Description of Small molecules (Chemicals, Antibiotics,Mycotoxins,Hormones,Drugs of Abuse, etc.)

Sildenafil is an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection. In the smooth muscle of the pulmonary vasculature, the increase in cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed, relieving pulmonary hypertension and increasing blood flow in the lungs. In addition, sildenafil may reduce airway inflammation and mucus production.

Sildenafil functions as a selective and competitive inhibitor of type 5 phosphodiesterases (PDE5) on smooth muscle cells in the penis and pulmonary vasculature, and is used extensively for erectile dysfunction and less commonly for pulmonary hypertension. Sildenafil has been associated with rare instances of clinically apparent liver injury.

Sildenafil is a pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position. It has a role as a vasodilator agent and an EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor. It is a pyrazolopyrimidine, a member of piperazines and a sulfonamide.

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Delivery impact due to the Coronavirus Outbreak

With the COVID-19 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Catalog No. Description Price(In USD) Qty (Quantity) Sum(In USD)
GMP-SMT-209-1 1. BSA-Sildenafil(SDN); Size:1mg
2. Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:1mg
1365
GMP-SMT-209-1 1. BSA-Sildenafil(SDN); Size:10mg
2. Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:10mg
8232
GMP-SMT-209-1 1. BSA-Sildenafil(SDN); Size:100mg
2. Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:100mg
41160
GMP-SMT-209-2 1. OVA-Sildenafil(SDN); Size:1mg
2. Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:1mg
1365
GMP-SMT-209-2 1. OVA-Sildenafil(SDN); Size:10mg
2. Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:10mg
8232
GMP-SMT-209-2 1. OVA-Sildenafil(SDN); Size:100mg
2. Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:100mg
41160
GMP-SMT-209-Ab-1 Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:1mg 1043
GMP-SMT-209-Ab-1 Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:10mg 6272
GMP-SMT-209-Ab-1 Anti-Sildenafil(SDN) mouse monoclonal antibody; Size:100mg 31360
GMP-SMT-209-Ag-1 BSA-Sildenafil(SDN); Size:1mg 756
GMP-SMT-209-Ag-1 BSA-Sildenafil(SDN); Size:10mg 4536
GMP-SMT-209-Ag-1 BSA-Sildenafil(SDN); Size:100mg 22960
GMP-SMT-209-Ag-2 OVA-Sildenafil(SDN); Size:1mg 756
GMP-SMT-209-Ag-2 OVA-Sildenafil(SDN); Size:10mg 4536
GMP-SMT-209-Ag-2 OVA-Sildenafil(SDN); Size:100mg 22960
GMP-SMT-209 ≥100mg Inquiry
Shipping Cost: 760.00
Total:



Description


BSA-Sildenafil(SDN)

Cat No. GMP-SMT-209-Ag-1
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [BSA-Sildenafil(SDN)]with anti-Hapten antibody. The hapten hapten-carrier conjugates [BSA-Sildenafil(SDN)] had been validated with our anti-Hapten antibody[Anti-Sildenafil(SDN) mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


OVA-Sildenafil(SDN)

Cat No. GMP-SMT-209-Ag-2
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [ OVA-Sildenafil(SDN)] with anti-Hapten antibody. The hapten hapten-carrier conjugates[ OVA-Sildenafil(SDN)] had been validated with our anti-Hapten antibody[Anti-Sildenafil(SDN) mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Anti-Sildenafil(SDN) mouse monoclonal antibody

Cat No. GMP-SMT-209-Ab-1
Host of Antibody Mouse IgG
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb) 0.4-0.5
Products description The anti-Hapten antibody against hapten [Sildenafil(SDN)] had beenvalidated with our hapten hapten-carrier conjugates [BSA-Sildenafil(SDN)] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.