EGFR: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of EGFR. The page also collects GeneMedi's different modalities and formats products for EGFR in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the EGFR target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]
|Gene Symbol and Synonyms||9030024J15Rik,EGFR,ERBB,ErbB-1,ERBB1,Errb1,ERRP,HER1,mENA,NISBD2,PIG61,wa-2,wa2,Wa5|
|Uniprot Entry Name||EGFR_HUMAN,EGFR_MACMU|
|Protein Sub-location||Transmembrane Protein|
|Category||Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target|
|Disease||Breast Cancer, Non-Small Cell Lung Cancer, gastric cancer, apoptosis, Asphyxia neonatorum, Urinary bladder urothelial carcinoma|
|Target Classification||Checkpoint-Immuno Oncology, Kinase|
Pre-made EGFR-specific INN-index biosimilar (antibody&conjugates)
Anti-EGFR therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-EGFR inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-EGFR benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-EGFR mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
|Antibody Name||Species||Format||Classified by tag||Detail|
|Anti-EGFR monoclonal antibody||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||mab||FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody||Detail|
Multi-species EGFR/ ERBB/ ERBB1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine EGFR VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
|Products Name||Species||Expression Platform||Detail|
|EGFR VLP (virus-like particle)||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||Mammalian cell||Products Developing|
Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse epidermal growth factor receptor (EGFR) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.? The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer.? Epidermal growth factor and its receptor was discovered by Stanley Cohen of Vanderbilt University. Cohen shared the 1986 Nobel Prize in Medicine with Rita Levi-Montalcini for their discovery of growth factors.? Deficient signaling of the EGFR and other receptor tyrosine kinases in humans is associated with diseases such as Alzheimer's, while over-expression is associated with the development of a wide variety of tumors. Interruption of EGFR signalling, either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumours and improve the patient's condition
|Target||Species||Antigen Product Name||Bioactivity validation of Antigen||Antibody Product Name||Bioactivity validation of Antibodies||Detail|
|EGFR||Human, Cynomolgus/Rhesus macaque, rat, mouse||epidermal growth factor receptor (EGFR) protein||Affintiy&bioactivity validated by ELISA, cell culture validated||Anti-EGFR monoclonal antibody||Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).||Detail|
Click to check more Cytokine Products
Pre-made EGFR viral vector in GM Promise-ORFTM
|Cat No.||Products name||NM ID||Species||Type||Detail|
|pGMLV000508||human EGFR Lentivirus plasmid||NM_005228.4||Human||Lentivirus plasmid||Detail|
|vGMLV000508||human EGFR Lentivirus particle||NM_005228.4||Human||Lentivirus particle||Detail|
|pGMAD000182||human EGFR Adenovirus plasmid||NM_005228.3||Human||Adenovirus plasmid||Detail|
|pGMLV000217||human EGFR Lentivirus plasmid||NM_005228.3||Human||Lentivirus plasmid||Detail|
|vGMLV000217||human EGFR Lentivirus particle||NM_005228.3||Human||Lentivirus particle||Detail|
|vGMLV000216||human EGFR Lentivirus particle||NM_005228.4||Human||Lentivirus particle||Detail|
|pGMLV000216||human EGFR Lentivirus plasmid||NM_005228.4||Human||Lentivirus plasmid||Detail|
|vGMAD000182||human EGFR Adenovirus particle||NM_005228.3||Human||Adenovirus particle||Detail|
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.