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Anti-EGFR/ ERBB/ ERBB1 monoclonal antibody
Anti-EGFR/ ERBB/ ERBB1 antibody for FACS & in-vivo assay
Go to EGFR/EGFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59328-Ab-1/ GM-Tg-hg-T59328-Ab-2 | Anti-Human EGFR monoclonal antibody | Human |
| GM-Tg-rg-T59328-Ab-1/ GM-Tg-rg-T59328-Ab-2 | Anti-Rat EGFR monoclonal antibody | Rat |
| GM-Tg-mg-T59328-Ab-1/ GM-Tg-mg-T59328-Ab-2 | Anti-Mouse EGFR monoclonal antibody | Mouse |
| GM-Tg-cynog-T59328-Ab-1/ GM-Tg-cynog-T59328-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EGFR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59328-Ab-1/ GM-Tg-felg-T59328-Ab-2 | Anti-Feline EGFR monoclonal antibody | Feline |
| GM-Tg-cang-T59328-Ab-1/ GM-Tg-cang-T59328-Ab-2 | Anti-Canine EGFR monoclonal antibody | Canine |
| GM-Tg-bovg-T59328-Ab-1/ GM-Tg-bovg-T59328-Ab-2 | Anti-Bovine EGFR monoclonal antibody | Bovine |
| GM-Tg-equg-T59328-Ab-1/ GM-Tg-equg-T59328-Ab-2 | Anti-Equine EGFR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59328-Ab-1/ GM-Tg-hg-T59328-Ab-2; GM-Tg-rg-T59328-Ab-1/ GM-Tg-rg-T59328-Ab-2; GM-Tg-mg-T59328-Ab-1/ GM-Tg-mg-T59328-Ab-2; GM-Tg-cynog-T59328-Ab-1/ GM-Tg-cynog-T59328-Ab-2; GM-Tg-felg-T59328-Ab-1/ GM-Tg-felg-T59328-Ab-2; GM-Tg-cang-T59328-Ab-1/ GM-Tg-cang-T59328-Ab-2; GM-Tg-bovg-T59328-Ab-1/ GM-Tg-bovg-T59328-Ab-2; GM-Tg-equg-T59328-Ab-1/ GM-Tg-equg-T59328-Ab-2 |
| Products Name | Anti-EGFR monoclonal antibody |
| Format | mab |
| Target Name | EGFR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EGFR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T59328 |
| Target Name | EGFR |
| Gene ID | 1956,13649,24329,613027,404306,100510799,407217,100067755 |
| Gene Symbol and Synonyms | 9030024J15Rik,EGFR,ERBB,ErbB-1,ERBB1,Errb1,ERRP,HER1,mENA,NISBD2,PIG61,wa-2,wa2,Wa5 |
| Uniprot Accession | P00533,P55245 |
| Uniprot Entry Name | EGFR_HUMAN,EGFR_MACMU |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Breast Cancer, Non-Small Cell Lung Cancer, gastric cancer, apoptosis, Asphyxia neonatorum, Urinary bladder urothelial carcinoma |
| Gene Ensembl | ENSG00000146648 |
| Target Classification | Checkpoint-Immuno Oncology, Kinase |
The target: EGFR, gene name: EGFR, also named as ERBB, ERBB1, HER1, NISBD2, PIG61, mENA. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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