Recombinant multi-species NRG3/ HRG3/ pro-NRG3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NRG3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: NRG3, gene name: NRG3, also named as HRG3, pro-NRG3. This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-SE0375-Ag-1	Human NRG3 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-SE0375-Ag-1	Rat NRG3 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-SE0375-Ag-1	Mouse NRG3 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-SE0375-Ag-1	Cynomolgus/ Rhesus macaque NRG3 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-SE0375-Ag-1	Feline NRG3 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-SE0375-Ag-1	Canine NRG3 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-SE0375-Ag-1	Bovine NRG3 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-SE0375-Ag-1	Equine NRG3 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-SE0375-Ag, GM-Tg-rg-SE0375-Ag, GM-Tg-mg-SE0375-Ag, GM-Tg-cynog-SE0375-Ag, GM-Tg-felg-SE0375-Ag, GM-Tg-cang-SE0375-Ag, GM-Tg-bovg-SE0375-Ag, GM-Tg-equg-SE0375-Ag-1
Products Name	NRG3 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	NRG3
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NRG3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.