Recombinant multi-species SELN/ SELENON/ CFTD protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SELENON protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: SELENON, gene name: SELENON, also named as CFTD, MDRS1, RSMD1, RSS, SELN, SEPN1. This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-SE1555-Ag-1	Human SELENON protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-SE1555-Ag-1	Rat SELENON protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-SE1555-Ag-1	Mouse SELENON protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-SE1555-Ag-1	Cynomolgus/ Rhesus macaque SELENON protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-SE1555-Ag-1	Feline SELENON protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-SE1555-Ag-1	Canine SELENON protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-SE1555-Ag-1	Bovine SELENON protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-SE1555-Ag-1	Equine SELENON protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-SE1555-Ag, GM-Tg-rg-SE1555-Ag, GM-Tg-mg-SE1555-Ag, GM-Tg-cynog-SE1555-Ag, GM-Tg-felg-SE1555-Ag, GM-Tg-cang-SE1555-Ag, GM-Tg-bovg-SE1555-Ag, GM-Tg-equg-SE1555-Ag-1
Products Name	SELENON protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	SELENON
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SELENON protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.