Recombinant multi-species LOX5/ 5-LOX/ ALOX5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 5-LOX/ALOX5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: 5-LOX, gene name: ALOX5, also named as 5-LO, 5-LOX, 5LPG, LOG5. This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T00140-Ag-1	Human 5-LOX/ALOX5 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T00140-Ag-1	Rat 5-LOX/ALOX5 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T00140-Ag-1	Mouse 5-LOX/ALOX5 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T00140-Ag-1	Cynomolgus/ Rhesus macaque 5-LOX/ALOX5 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T00140-Ag-1	Feline 5-LOX/ALOX5 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T00140-Ag-1	Canine 5-LOX/ALOX5 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T00140-Ag-1	Bovine 5-LOX/ALOX5 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T00140-Ag-1	Equine 5-LOX/ALOX5 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T00140-Ag, GM-Tg-rg-T00140-Ag, GM-Tg-mg-T00140-Ag, GM-Tg-cynog-T00140-Ag, GM-Tg-felg-T00140-Ag, GM-Tg-cang-T00140-Ag, GM-Tg-bovg-T00140-Ag, GM-Tg-equg-T00140-Ag-1
Products Name	5-LOX/ALOX5 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	5-LOX
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 5-LOX/ALOX5 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.