Recombinant multi-species ABL1/ ABL T315I/ ABL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABL T315I/ABL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: ABL T315I, gene name: ABL1, also named as ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T00348-Ag-1	Human ABL T315I/ABL1 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T00348-Ag-1	Rat ABL T315I/ABL1 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T00348-Ag-1	Mouse ABL T315I/ABL1 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T00348-Ag-1	Cynomolgus/ Rhesus macaque ABL T315I/ABL1 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T00348-Ag-1	Feline ABL T315I/ABL1 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T00348-Ag-1	Canine ABL T315I/ABL1 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T00348-Ag-1	Bovine ABL T315I/ABL1 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T00348-Ag-1	Equine ABL T315I/ABL1 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T00348-Ag, GM-Tg-rg-T00348-Ag, GM-Tg-mg-T00348-Ag, GM-Tg-cynog-T00348-Ag, GM-Tg-felg-T00348-Ag, GM-Tg-cang-T00348-Ag, GM-Tg-bovg-T00348-Ag, GM-Tg-equg-T00348-Ag-1
Products Name	ABL T315I/ABL1 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	ABL T315I
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABL T315I/ABL1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.