Recombinant multi-species CDN2A/ ARF/ CDKN2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDKN2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: CDKN2A, gene name: CDKN2A, also named as ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16. This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T16452-Ag-1	Human CDKN2A protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T16452-Ag-1	Rat CDKN2A protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T16452-Ag-1	Mouse CDKN2A protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T16452-Ag-1	Cynomolgus/ Rhesus macaque CDKN2A protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T16452-Ag-1	Feline CDKN2A protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T16452-Ag-1	Canine CDKN2A protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T16452-Ag-1	Bovine CDKN2A protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T16452-Ag-1	Equine CDKN2A protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T16452-Ag, GM-Tg-rg-T16452-Ag, GM-Tg-mg-T16452-Ag, GM-Tg-cynog-T16452-Ag, GM-Tg-felg-T16452-Ag, GM-Tg-cang-T16452-Ag, GM-Tg-bovg-T16452-Ag, GM-Tg-equg-T16452-Ag-1
Products Name	CDKN2A protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	CDKN2A
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDKN2A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.