Recombinant multi-species ERN1/ IRE1a/ IRE1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IRE1a/ERN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: IRE1a, gene name: ERN1, also named as IRE1, IRE1P, IRE1a, hIRE1p. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017].

Order information

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T17656-Ag-1	Human IRE1a/ERN1 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T17656-Ag-1	Rat IRE1a/ERN1 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T17656-Ag-1	Mouse IRE1a/ERN1 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T17656-Ag-1	Cynomolgus/ Rhesus macaque IRE1a/ERN1 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T17656-Ag-1	Feline IRE1a/ERN1 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T17656-Ag-1	Canine IRE1a/ERN1 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T17656-Ag-1	Bovine IRE1a/ERN1 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T17656-Ag-1	Equine IRE1a/ERN1 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T17656-Ag, GM-Tg-rg-T17656-Ag, GM-Tg-mg-T17656-Ag, GM-Tg-cynog-T17656-Ag, GM-Tg-felg-T17656-Ag, GM-Tg-cang-T17656-Ag, GM-Tg-bovg-T17656-Ag, GM-Tg-equg-T17656-Ag-1
Products Name	IRE1a/ERN1 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	IRE1a
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IRE1a/ERN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.