Recombinant multi-species GCH1/ DYT14/ DYT5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Target products collectionGo to GCH1/GCH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: GCH1, gene name: GCH1, also named as DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B. This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T28226-Ag-1Human GCH1 proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T28226-Ag-1Rat GCH1 proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T28226-Ag-1Mouse GCH1 proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T28226-Ag-1Cynomolgus/ Rhesus macaque GCH1 proteinCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T28226-Ag-1Feline GCH1 proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T28226-Ag-1Canine GCH1 proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T28226-Ag-1Bovine GCH1 proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T28226-Ag-1Equine GCH1 proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

For more than 100mg, click here forinquiry.>>


Description

Catalog No.GM-Tg-hg-T28226-Ag, GM-Tg-rg-T28226-Ag, GM-Tg-mg-T28226-Ag, GM-Tg-cynog-T28226-Ag,
GM-Tg-felg-T28226-Ag, GM-Tg-cang-T28226-Ag, GM-Tg-bovg-T28226-Ag, GM-Tg-equg-T28226-Ag-1
Products Name GCH1 protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameGCH1
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCH1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.