Recombinant multi-species NFKB1/ p105/ CVID12 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine p105/NFKB1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: p105, gene name: NFKB1, also named as CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B1, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50. This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T40192-Ag-1	Human p105/NFKB1 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T40192-Ag-1	Rat p105/NFKB1 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T40192-Ag-1	Mouse p105/NFKB1 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T40192-Ag-1	Cynomolgus/ Rhesus macaque p105/NFKB1 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T40192-Ag-1	Feline p105/NFKB1 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T40192-Ag-1	Canine p105/NFKB1 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T40192-Ag-1	Bovine p105/NFKB1 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T40192-Ag-1	Equine p105/NFKB1 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T40192-Ag, GM-Tg-rg-T40192-Ag, GM-Tg-mg-T40192-Ag, GM-Tg-cynog-T40192-Ag, GM-Tg-felg-T40192-Ag, GM-Tg-cang-T40192-Ag, GM-Tg-bovg-T40192-Ag, GM-Tg-equg-T40192-Ag-1
Products Name	p105/NFKB1 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	p105
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine p105/NFKB1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.