Recombinant multi-species ELNE/ NE/ ELANE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NE/ELANE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: NE, gene name: ELANE, also named as ELA2, GE, HLE, HNE, NE, PMN-E, SCN1. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T40332-Ag-1	Human NE/ELANE protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T40332-Ag-1	Rat NE/ELANE protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T40332-Ag-1	Mouse NE/ELANE protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T40332-Ag-1	Cynomolgus/ Rhesus macaque NE/ELANE protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T40332-Ag-1	Feline NE/ELANE protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T40332-Ag-1	Canine NE/ELANE protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T40332-Ag-1	Bovine NE/ELANE protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T40332-Ag-1	Equine NE/ELANE protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T40332-Ag, GM-Tg-rg-T40332-Ag, GM-Tg-mg-T40332-Ag, GM-Tg-cynog-T40332-Ag, GM-Tg-felg-T40332-Ag, GM-Tg-cang-T40332-Ag, GM-Tg-bovg-T40332-Ag, GM-Tg-equg-T40332-Ag-1
Products Name	NE/ELANE protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	NE
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NE/ELANE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.