Recombinant multi-species IL1B/ IL-1/ IL1-BETA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL1B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: IL1B, gene name: IL1B, also named as IL-1, IL1-BETA, IL1F2. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T42000-Ag-1	Human IL1B protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T42000-Ag-1	Rat IL1B protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T42000-Ag-1	Mouse IL1B protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T42000-Ag-1	Cynomolgus/ Rhesus macaque IL1B protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T42000-Ag-1	Feline IL1B protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T42000-Ag-1	Canine IL1B protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T42000-Ag-1	Bovine IL1B protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T42000-Ag-1	Equine IL1B protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T42000-Ag, GM-Tg-rg-T42000-Ag, GM-Tg-mg-T42000-Ag, GM-Tg-cynog-T42000-Ag, GM-Tg-felg-T42000-Ag, GM-Tg-cang-T42000-Ag, GM-Tg-bovg-T42000-Ag, GM-Tg-equg-T42000-Ag-1
Products Name	IL1B protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	IL1B
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL1B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.