Recombinant multi-species DHB1/ 17-beta-HSD1/ HSD17B1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 17-beta-HSD1/HSD17B1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: 17-beta-HSD1, gene name: HSD17B1, also named as 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1. This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T44011-Ag-1	Human 17-beta-HSD1/HSD17B1 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T44011-Ag-1	Rat 17-beta-HSD1/HSD17B1 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T44011-Ag-1	Mouse 17-beta-HSD1/HSD17B1 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T44011-Ag-1	Cynomolgus/ Rhesus macaque 17-beta-HSD1/HSD17B1 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T44011-Ag-1	Feline 17-beta-HSD1/HSD17B1 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T44011-Ag-1	Canine 17-beta-HSD1/HSD17B1 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T44011-Ag-1	Bovine 17-beta-HSD1/HSD17B1 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T44011-Ag-1	Equine 17-beta-HSD1/HSD17B1 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T44011-Ag, GM-Tg-rg-T44011-Ag, GM-Tg-mg-T44011-Ag, GM-Tg-cynog-T44011-Ag, GM-Tg-felg-T44011-Ag, GM-Tg-cang-T44011-Ag, GM-Tg-bovg-T44011-Ag, GM-Tg-equg-T44011-Ag-1
Products Name	17-beta-HSD1/HSD17B1 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	17-beta-HSD1
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 17-beta-HSD1/HSD17B1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.