Recombinant multi-species JAK1/ JAK-1/ JAK1AB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JAK-1/JAK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: JAK-1, gene name: JAK1, also named as JAK1AB, JTK3, JAK1. This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T62460-Ag-1	Human JAK-1/JAK1 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T62460-Ag-1	Rat JAK-1/JAK1 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T62460-Ag-1	Mouse JAK-1/JAK1 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T62460-Ag-1	Cynomolgus/ Rhesus macaque JAK-1/JAK1 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T62460-Ag-1	Feline JAK-1/JAK1 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T62460-Ag-1	Canine JAK-1/JAK1 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T62460-Ag-1	Bovine JAK-1/JAK1 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T62460-Ag-1	Equine JAK-1/JAK1 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T62460-Ag, GM-Tg-rg-T62460-Ag, GM-Tg-mg-T62460-Ag, GM-Tg-cynog-T62460-Ag, GM-Tg-felg-T62460-Ag, GM-Tg-cang-T62460-Ag, GM-Tg-bovg-T62460-Ag, GM-Tg-equg-T62460-Ag-1
Products Name	JAK-1/JAK1 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	JAK-1
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JAK-1/JAK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.