Recombinant multi-species NISCH/ I-1/ IR1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NISCH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: NISCH, gene name: NISCH, also named as I-1, IR1, IRAS, hIRAS. This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T65689-Ag-1	Human NISCH protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T65689-Ag-1	Rat NISCH protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T65689-Ag-1	Mouse NISCH protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T65689-Ag-1	Cynomolgus/ Rhesus macaque NISCH protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T65689-Ag-1	Feline NISCH protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T65689-Ag-1	Canine NISCH protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T65689-Ag-1	Bovine NISCH protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T65689-Ag-1	Equine NISCH protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T65689-Ag, GM-Tg-rg-T65689-Ag, GM-Tg-mg-T65689-Ag, GM-Tg-cynog-T65689-Ag, GM-Tg-felg-T65689-Ag, GM-Tg-cang-T65689-Ag, GM-Tg-bovg-T65689-Ag, GM-Tg-equg-T65689-Ag-1
Products Name	NISCH protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	NISCH
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NISCH protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.