Recombinant multi-species MK14/ p38 alpha/ MAPK14 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine p38 alpha/MAPK14 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: p38 alpha, gene name: MAPK14, also named as CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T65864-Ag-1	Human p38 alpha/MAPK14 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T65864-Ag-1	Rat p38 alpha/MAPK14 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T65864-Ag-1	Mouse p38 alpha/MAPK14 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T65864-Ag-1	Cynomolgus/ Rhesus macaque p38 alpha/MAPK14 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T65864-Ag-1	Feline p38 alpha/MAPK14 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T65864-Ag-1	Canine p38 alpha/MAPK14 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T65864-Ag-1	Bovine p38 alpha/MAPK14 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T65864-Ag-1	Equine p38 alpha/MAPK14 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T65864-Ag, GM-Tg-rg-T65864-Ag, GM-Tg-mg-T65864-Ag, GM-Tg-cynog-T65864-Ag, GM-Tg-felg-T65864-Ag, GM-Tg-cang-T65864-Ag, GM-Tg-bovg-T65864-Ag, GM-Tg-equg-T65864-Ag-1
Products Name	p38 alpha/MAPK14 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	p38 alpha
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine p38 alpha/MAPK14 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.