Recombinant multi-species CCN4/ WISP1/ WISP1-OT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WISP1/CCN4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: WISP1, gene name: CCN4, also named as WISP1, WISP1-OT1, WISP1-UT1, WISP1c, WISP1i, WISP1tc. This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T71859-Ag-1	Human WISP1/CCN4 protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T71859-Ag-1	Rat WISP1/CCN4 protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T71859-Ag-1	Mouse WISP1/CCN4 protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T71859-Ag-1	Cynomolgus/ Rhesus macaque WISP1/CCN4 protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T71859-Ag-1	Feline WISP1/CCN4 protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T71859-Ag-1	Canine WISP1/CCN4 protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T71859-Ag-1	Bovine WISP1/CCN4 protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T71859-Ag-1	Equine WISP1/CCN4 protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T71859-Ag, GM-Tg-rg-T71859-Ag, GM-Tg-mg-T71859-Ag, GM-Tg-cynog-T71859-Ag, GM-Tg-felg-T71859-Ag, GM-Tg-cang-T71859-Ag, GM-Tg-bovg-T71859-Ag, GM-Tg-equg-T71859-Ag-1
Products Name	WISP1/CCN4 protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	WISP1
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WISP1/CCN4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.