Recombinant multi-species SMN/ SMN1/ BCD541 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Target products collectionGo to SMN1/SMN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: SMN1, gene name: SMN1, also named as BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3, SMA4, SMA@, SMN, SMNT, T-BCD541, TDRD16A. This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2014].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T71907-Ag-1Human SMN1 proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T71907-Ag-1Rat SMN1 proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T71907-Ag-1Mouse SMN1 proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T71907-Ag-1Cynomolgus/ Rhesus macaque SMN1 proteinCynomolgus/
Rhesus macaque
1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T71907-Ag-1Feline SMN1 proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T71907-Ag-1Canine SMN1 proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T71907-Ag-1Bovine SMN1 proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T71907-Ag-1Equine SMN1 proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00



Description

Catalog No.GM-Tg-hg-T71907-Ag, GM-Tg-rg-T71907-Ag, GM-Tg-mg-T71907-Ag, GM-Tg-cynog-T71907-Ag,
GM-Tg-felg-T71907-Ag, GM-Tg-cang-T71907-Ag, GM-Tg-bovg-T71907-Ag, GM-Tg-equg-T71907-Ag-1
Products Name SMN1 protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameSMN1
Protein Sub-locationIntrocelluar Protein
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
FormulationSupplied as a 0.2 μM filtered solution of PBS, PH7.4.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.