Recombinant multi-species IDE/ INSULYSIN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: IDE, gene name: IDE, also named as INSULYSIN. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T81900-Ag-1	Human IDE protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T81900-Ag-1	Rat IDE protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T81900-Ag-1	Mouse IDE protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T81900-Ag-1	Cynomolgus/ Rhesus macaque IDE protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T81900-Ag-1	Feline IDE protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T81900-Ag-1	Canine IDE protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T81900-Ag-1	Bovine IDE protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T81900-Ag-1	Equine IDE protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T81900-Ag, GM-Tg-rg-T81900-Ag, GM-Tg-mg-T81900-Ag, GM-Tg-cynog-T81900-Ag, GM-Tg-felg-T81900-Ag, GM-Tg-cang-T81900-Ag, GM-Tg-bovg-T81900-Ag, GM-Tg-equg-T81900-Ag-1
Products Name	IDE protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	IDE
Protein Sub-location	Secreted Protein/Potential Cytokines
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.