Recombinant multi-species DNAS1/ DNASE1/ DNL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Target products collectionGo to DNASE1/DNASE1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNASE1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: DNASE1, gene name: DNASE1, also named as DNL1, DRNI. This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

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Catalog No.Product NameSpeciesSizePrice
GM-Tg-hg-T85223-Ag-1Human DNASE1 proteinHuman1mg/10mg/100mg/≥100mgInquiry
GM-Tg-rg-T85223-Ag-1Rat DNASE1 proteinRat1mg/10mg/100mg/≥100mgInquiry
GM-Tg-mg-T85223-Ag-1Mouse DNASE1 proteinMouse1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cynog-T85223-Ag-1Cynomolgus/ Rhesus macaque DNASE1 proteinCynomolgus/
Rhesus macaque		1mg/10mg/100mg/≥100mgInquiry
GM-Tg-felg-T85223-Ag-1Feline DNASE1 proteinFeline1mg/10mg/100mg/≥100mgInquiry
GM-Tg-cang-T85223-Ag-1Canine DNASE1 proteinCanine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T85223-Ag-1Bovine DNASE1 proteinBovine1mg/10mg/100mg/≥100mgInquiry
GM-Tg-bovg-T85223-Ag-1Equine DNASE1 proteinEquine1mg/10mg/100mg/≥100mgInquiry
Shipping Cost:760.00

For more than 100mg, click here forinquiry.>>


Description

Catalog No.GM-Tg-hg-T85223-Ag, GM-Tg-rg-T85223-Ag, GM-Tg-mg-T85223-Ag, GM-Tg-cynog-T85223-Ag,
GM-Tg-felg-T85223-Ag, GM-Tg-cang-T85223-Ag, GM-Tg-bovg-T85223-Ag, GM-Tg-equg-T85223-Ag-1
Products Name DNASE1 protein
SpeciesHuman, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target NameDNASE1
Protein Sub-locationSecreted Protein/Potential Cytokines
IsotypesRecombinant protein
Expression platform Mammalian cell
Bioactivity validationAffintiy&bioactivity validated by ELISA, cell culture validated.
TagHis
Products descriptionRecombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNASE1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
PurityPurity: ≥95% (SDS-PAGE)
ApplicationIn vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & ReconstitutionLyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.