Recombinant multi-species TOP2B/ TOPIIB/ top2beta protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TOP2B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: TOP2B, gene name: TOP2B, also named as TOPIIB, top2beta. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T85733-Ag-1	Human TOP2B protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T85733-Ag-1	Rat TOP2B protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T85733-Ag-1	Mouse TOP2B protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T85733-Ag-1	Cynomolgus/ Rhesus macaque TOP2B protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T85733-Ag-1	Feline TOP2B protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T85733-Ag-1	Canine TOP2B protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T85733-Ag-1	Bovine TOP2B protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T85733-Ag-1	Equine TOP2B protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T85733-Ag, GM-Tg-rg-T85733-Ag, GM-Tg-mg-T85733-Ag, GM-Tg-cynog-T85733-Ag, GM-Tg-felg-T85733-Ag, GM-Tg-cang-T85733-Ag, GM-Tg-bovg-T85733-Ag, GM-Tg-equg-T85733-Ag-1
Products Name	TOP2B protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	TOP2B
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TOP2B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.